Sickle Cell Disease: Promoting Health for Children and Adolescents
By The Hospital for Sick Children (SickKids) and Ghana College of Nurses and Midwives
Sickle Cell Disease: Promoting Health for Children and Adolescents explores the lived experience of children and adolescents with sickle cell disease and their families. The course features interactive content that will provide healthcare workers with the knowledge they need to improve care, quality of life, and health outcomes....
Common Cancers in the Dental Patient Population
StJohn Crean, Rishi Bhandari
0.5 Hours
This session describes the signs and symptoms that may manifest in patients diagnosed with cancers and looks at the impact of important cancers on the provision of dental care.
Prise en charge de saignements graves après l’accouchement
GHM
Managing Severe Bleeding After Birth - Prise en charge de saignements graves après l’accouchement
Understanding Diabetes and Hypertension: Symptoms, Risk Factors and Treatment
The International Rescue Committee Non-Communicable Diseases Consortium Project
Medical Aid Films This animation aims to help community health workers in humanitarian settings gain a better understanding of two common non-communicable diseases - diabetes and hypertension - including their symptoms, associated risk factors and treatment. It was produced for The International Rescue Committee Non-Communicabl....
Sickle Cell Disease: Acute Management in Children and Adolescents
By The Hospital for Sick Children (SickKids) and Ghana College of Nurses and Midwives
This course is part of a series on Sickle Cell Diseases by the SickKids-Ghana Paediatric Nursing Education Partnership. The series was developed for healthcare workers (nurses, community health nurses, midwives, and physicians) in Ghana, but has broad relevance for healthcare workers in the region and globally. It is recommended....
Developing a Transition Programme
Janet McDonagh, Anita Morgan and Marcelle Sousa
0.5 Hours
This session considers the key steps involved in the development of a transitional care programme for young people with long-term conditions and/or disabilities.
Case Report: Neuroleptic malignant syndrome in a HIV-positive patient
Sibi Joseph,Jerry George,Mongezi Tau,Lourdes de Fatima Ibanez-Valdes,Thozama Dubula,Humberto Foyaca-Sibat
Most authors define neuroleptic malignant syndrome (NMS) as a rare, yet life-threatening, idiosyncratic reaction to medications, mostly but not limited to neuroleptic drugs (dopamine receptor antagonists). NMS was initially described by Delay and colleagues in 1960, who noticed it in patients treated with high-potency antipsycho....
Case Report: rare hybrid lesion of a central giant cell granuloma within a juvenile ossifying fibroma
Hadeer Rizk Saad,Noura M. Kamal,Hatem W. Amer
Central giant cell granuloma (CGCG) is believed to be an entity exclusive to jaw bones. The term “benign fibro-osseous lesions” generically describes an aggregate of pathologies that are characterized by replacement of normal bone with a highly cellular connective tissue associated with newly formed bone trabeculae. Radiographic....
Development of a simple and valid nutrition screening tool for pediatric hospitalized patients with acute illness
Hoda Atef Abdelsattar Ibrahim,Rasha Abdel-Raouf,Ahmed S. Zeid,Eman H. Elsebaie,Shaimaa Abdalaleem,Aya A. Amin,Hanna Aboulghar
Nutrition is an essential factor in the development, growth, and functioning of any child. Good nutritional status provides energy and nutrients which are essential to maintain our life and promote social, physical, emotional, and cognitive development. Childhood malnutrition is known to be a global health concern as it is compl....
Knowledge and compliance with Covid-19 infection prevention and control measures among health workers in regional referral hospitals in northern Uganda: a cross-sectional online survey
Sharon Bright Amanya,Richard Nyeko,Bonniface Obura,Joy Acen,Caroline Nabasirye,Rebecca Nakaziba,Florence Oyella,Victor Afayo,Mark Okwir
Coronavirus disease 2019 (Covid-19) is arguably the greatest global health threat of our time. As of January 24, 2021, 19,462,112 people were infected globally, with 2,112,759 deaths. The World Health Organization (WHO) issued interim guidance on Covid-19 IPC that emphasized several measures, including applying standard precauti....
In vitro regulation of reactive oxygen species formation in red blood cells of homozygous sickle cell patients using Vitamin C
Ogechukwu Egini,Edouard Guillaume,Titilope Adeyemo,Chiemeziem Nwanyanwu,Fnu Shweta,Eric Jaffe
Sickle cell anemia is a single-nucleotide polymorphism due to substitution of glutamic acid by valine at position 6 of the B-globin chain. ROS formation is maximal during the reperfusion state when there is increased formation of methemoglobin and superoxide ion due to electron transfers that occur between the heme iron and oxyg....
Knowledge of pastoralists on livestock diseases and exposure assessment to brucellosis within rural and peri-urban areas in Kajiado, Kenya
Joshua Onono,Penina Mutua,Philip Kitala,Peter Gathura
Brucellosis is a neglected bacterial zoonosis with global distribution, and it has been reported in 56 countries with more than 500,000 new human cases reported annually (. In Kenya, brucellosis was first reported in 1916 with the first case confirmed in a laboratory in 1931 (. The pastoralist communities are highly dependent on....
Streptococcus pneumoniae Serotype Epidemiology among PCV-10 Vaccinated and Unvaccinated Children at Gertrude’s Children’s Hospital, Nairobi County: A Cross-Sectional Study
Michael Walekhwa,Margaret Muturi,Revathi Gunturu,Eucharia Kenya,Beatrice Kabera
is a friendly gram positive inhabitant of the human upper respiratory tract but can be highly invasive in some conditions (. Some strains also have a greater potential to develop antibiotic resistance than others (. vaccines protect against several severe forms of pneumococcal disease, such as meningitis, pneumonia and bacterem....
Revisiting early-stage COVID-19 strategy options
Philip Machanick
When I first submitted this paper in May 2020, I wrote with some urgency because I believed the issue of asymptomatic transmission of COVID-19 was not receiving the attention it deserved, and updated the paper before any reviews were in. All the versions of the paper, read in conjunction of the reviews, form a living review, sho....
Continuous and intermittent exposure of neonatal rat calvarial cells to PTHrP (1-36) inhibits bone nodule mineralization in vitro by downregulating bone sialoprotein expression via the cAMP signaling pathway
Suzan A Kamel,John A Yee
Parathyroid-hormone-related protein (PTHrP) is the causative factor of humoral hypercalcemia of malignancy. The amino terminus of PTHrP has strong homology with the comparable region of parathyroid hormone (PTH). In several tissues, including bone, it has been reported that PTHrP and PTH1R mRNAs and/or proteins are expressed by....
Post-Ebola Community Health Worker programme performance in Kenema District, Sierra Leone: A long way to go!
Harold Thomas,Katrina Hann,Mohamed Vandi,Joseph Bengalie Sesay,Koi Sylvester Alpha,Robinah Najjemba
The effect of the 2014–2015 West African Ebola outbreak on Community Health Worker (CHW) services in Kenema district, Sierra Leone, was assessed through a retrospective cross-sectional study comparing CHW reporting and services before (June 2013-April 2014), during (June 2014-April 2015) and post-outbreak (November 2015-April 20....
Could night-guards be used as a simple method to detect leached-elements from dental restorations intra-orally? A study on amalgam restorations
Rasha Mohamed Abdelraouf
Determination of leached-elements from dental restorations has been investigated as a result of exposure to oral conditions. On the other hand,. Yet, measuring the released elements in humans may be best. Several studies quantified the excretion of mercury in urine, hair and nails of patients with dental amalgam-restorations and....
Non-AIDS defining malignancies in the combination ART era: immunological and socio-behavioral risk factors
Yann Ruffieux,Frédérique Chammartin,Anita Feller,Kurt Schmidlin,Sabine Rohrmann,Katharina Staehelin,Christine Bouchardy,Heiner C. Bucher,Barbara Hasse,Matthias Cavassini,Alexandra Calmy,Gilles Wandeler,Alexandra Scherrer,Julia Bohlius,Matthias Egger
In high-income countries, life expectancy of people living with HIV (PLWHIV) on combination antiretroviral therapy (cART) is approaching that of the general population. An analysis of causes of death in the Data collection on Adverse events of Anti-HIV Drugs (a collaboration of eleven HIV cohort studies from Europe, the USA and....
Virologic failure and HIV drug resistance on simplified, dolutegravir-based maintenance therapy: Systematic review and meta-analysis
Gilles Wandeler,Marta Buzzi,Nanina Anderegg,Delphine Sculier,Charles Béguelin,Matthias Egger,Alexandra Calmy
The concept of combination antiretroviral therapy (ART) for the treatment of HIV infection was established twenty years ago, when the results of the first studies evaluating protease inhibitor-based regimens were published. Due to its interesting pharmacokinetic profile, good tolerability and high barrier to resistance, dolutegr....
Hub genes in a pan-cancer co-expression network show potential for predicting drug responses
Francisco Azuaje,Tony Kaoma,Céline Jeanty,Petr V. Nazarov,Arnaud Muller,Sang-Yoon Kim,Gunnar Dittmar,Anna Golebiewska,Simone P. Niclou
The analysis of networks extracted from different types of “omics” data is a useful strategy to enable the characterization and prediction of meaningful properties of the underlying complex biological systems. Addressing the above-mentioned challenge is now possible thanks to the availability of large collections of data origina....
Early assessment of antiretroviral efficacy is critical to prevent the emergence of resistance mutations in HIV-tuberculosis coinfected patients: a substudy of the CARINEMO-ANRS12146 trial
Elisabeth Baudin,Nilesh Bhatt,Christine Rouzioux,Micaela Serafini,Lucas Molfino,Ilesh Jani,Anne-Marie Taburet,Maryline Bonnet,Alexandra Calmy
Antiretroviral therapy (ART) aims to sustain virological suppression, which is associated with a clinical benefit and immune recovery. It also prevents HIV transmission and limits the emergence of antiretroviral (ARV) drug resistance. In a recent meta-analysis, Gupta. In 2016, 80% of the worldwide prescription of ART-included ef....
A real-world intention-to-treat analysis of a decade’s experience of treatment of hepatitis C with interferon-based therapies
Nowlan Selvapatt,Ashley Brown
Data from the World Health Organization suggest that 130–150 million people are infected with chronic hepatitis C worldwide, a significant proportion of whom will develop liver cirrhosis or cancer. There are seven known genotypes of HCV, although it is possible for patients to be infected with more than one genotype concurrently....
CA72-4 may contribute to real-time reconnaissance of gastric cancer
Jutta Keller,Ella Reiss-Sklan,Miri Refael,Viola Andresen,Yael Levy-Herman,Igor Ruvinsky
Despite continuous decline in incidence rates in both sexes, gastric cancer is still the fourth most common cancer worldwide, with 934,000 newly diagnosed cases per year. As new potential screening methodologies, such as capsule endoscopyn
Coronavirus disease 2019 drug discovery through molecular docking
Sweta Singh,Hector Florez
Coronavirus Disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), that is responsible for respiratory illness and probably many more is yet to be discovered. This novel virus was first identified on 30. Then, it is necessary for the rapid development and approval of a vaccine, whi....
The effect of silver nanoparticles incorporation in the self-etch adhesive system on its antibacterial activity and degree of conversion: an in-vitro study
Heba F. Mohammed,Mona I. Riad
Dental resin composite is a widely used restorative material that has superior aesthetic properties and strong bonding ability to the tooth structure in comparison to other restorative materials like amalgam. Silver is an antimicrobial agent that has broad spectrum activity against gram positive and gram negative bacterian....