Virologic failure and HIV drug resistance on simplified, dolutegravir-based maintenance therapy: Systematic review and meta-analysis
Gilles Wandeler,Marta Buzzi,Nanina Anderegg,Delphine Sculier,Charles Béguelin,Matthias Egger,Alexandra Calmy
The concept of combination antiretroviral therapy (ART) for the treatment of HIV infection was established twenty years ago, when the results of the first studies evaluating protease inhibitor-based regimens were published. Due to its interesting pharmacokinetic profile, good tolerability and high barrier to resistance, dolutegr....
Hub genes in a pan-cancer co-expression network show potential for predicting drug responses
Francisco Azuaje,Tony Kaoma,Céline Jeanty,Petr V. Nazarov,Arnaud Muller,Sang-Yoon Kim,Gunnar Dittmar,Anna Golebiewska,Simone P. Niclou
The analysis of networks extracted from different types of “omics” data is a useful strategy to enable the characterization and prediction of meaningful properties of the underlying complex biological systems. Addressing the above-mentioned challenge is now possible thanks to the availability of large collections of data origina....
Early assessment of antiretroviral efficacy is critical to prevent the emergence of resistance mutations in HIV-tuberculosis coinfected patients: a substudy of the CARINEMO-ANRS12146 trial
Elisabeth Baudin,Nilesh Bhatt,Christine Rouzioux,Micaela Serafini,Lucas Molfino,Ilesh Jani,Anne-Marie Taburet,Maryline Bonnet,Alexandra Calmy
Antiretroviral therapy (ART) aims to sustain virological suppression, which is associated with a clinical benefit and immune recovery. It also prevents HIV transmission and limits the emergence of antiretroviral (ARV) drug resistance. In a recent meta-analysis, Gupta. In 2016, 80% of the worldwide prescription of ART-included ef....
A real-world intention-to-treat analysis of a decade’s experience of treatment of hepatitis C with interferon-based therapies
Nowlan Selvapatt,Ashley Brown
Data from the World Health Organization suggest that 130–150 million people are infected with chronic hepatitis C worldwide, a significant proportion of whom will develop liver cirrhosis or cancer. There are seven known genotypes of HCV, although it is possible for patients to be infected with more than one genotype concurrently....
CA72-4 may contribute to real-time reconnaissance of gastric cancer
Jutta Keller,Ella Reiss-Sklan,Miri Refael,Viola Andresen,Yael Levy-Herman,Igor Ruvinsky
Despite continuous decline in incidence rates in both sexes, gastric cancer is still the fourth most common cancer worldwide, with 934,000 newly diagnosed cases per year. As new potential screening methodologies, such as capsule endoscopyn
Coronavirus disease 2019 drug discovery through molecular docking
Sweta Singh,Hector Florez
Coronavirus Disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), that is responsible for respiratory illness and probably many more is yet to be discovered. This novel virus was first identified on 30. Then, it is necessary for the rapid development and approval of a vaccine, whi....
The effect of silver nanoparticles incorporation in the self-etch adhesive system on its antibacterial activity and degree of conversion: an in-vitro study
Heba F. Mohammed,Mona I. Riad
Dental resin composite is a widely used restorative material that has superior aesthetic properties and strong bonding ability to the tooth structure in comparison to other restorative materials like amalgam. Silver is an antimicrobial agent that has broad spectrum activity against gram positive and gram negative bacterian....
Cell growth inhibition and apoptotic effects of a specific anti-RTFscFv antibody on prostate cancer, but not glioblastoma, cells
Foroogh Nejatollahi,Payam Bayat,Bahareh Moazen
Prostate cancer is the most prevalent malignancy and the second leading cause of cancer-related death among men in the USA and developing countries. Recombinant DNA technology paved the way for the production of recombinant antibody (rAb) fragments, such as single-chain variable fragment (scFv) antibodies, which are composed of....
The prevalence of dental caries among Egyptian children and adolescences and its association with age, socioeconomic status, dietary habits and other risk factors. A cross-sectional study
Marwa M.S. Abbass,Sara Ahmed Mahmoud,Sara El Moshy,Dina Rady,Nermeen AbuBakr,Israa Ahmed Radwan,Attera Ahmed,Ahmed Abdou,Ayoub Al-Jawaldeh
Dental caries is a major public health issue and it is the most widespread chronic disease. In children, dental caries pattern depends on the timing of tooth eruption as well as harmful dietary habit. Therefore, age is considered as an important factor that affects dental caries prevalence in children. It has been estimated that....
Evaluation of retention of knowledge, skill and competency of health workers one year after completion of the Helping Babies Breathe training program in South Sudan
Christopher Vunni Draiko,Khemika Yamarat,Alessio Panza,Judith Draleru
Of the 200,000 children born annually in South Sudan, an estimated 40% die in the first month of life. The transition from intrauterine to extra uterine life requires initiation of breathing which is critical physiological changes required for newborn survival. Research indicates that the majority of newborns initiate breathing....
Fracture resistance and 3D finite element analysis of machined ceramic crowns bonded to endodontically treated molars with two planes versus flat occlusal preparation designs: an in vitro study
Omnia Nabil,Carl Hany Halim,Ashraf Hassan Mokhtar
The best line of treatment to restore root canal treated teeth is one of the highly considered and debatable subjects. The breakthrough of adhesion in dentistry has enhanced the techniques of restoration of endodontically treated teeth. Adhesive composite resin and glass fiber posts have superseded the previously used non-bonded....
Evaluation of postoperative pain in infected root canals after using double antibiotic paste versus calcium hydroxide as intra-canal medication: A randomized controlled trial
Sarah Samir Abouelenien,Salsaby Mohamed Ibrahim,Olfat Gamil Shaker,Geraldine Mohamed Ahmed
Pain is the main symptom in many medical and dental conditions that can significantly alter the person’s general functioning. Several intra-canal medications have been used, including calcium hydroxide which is the most widely used intra-canal medication. It is characterized by its initial bactericidal, bacteriostatic effect and....
Antimicrobial resistance surveillance among gram-negative bacterial isolates from patients in hospitals in Khartoum State, Sudan
Hana Salaheldin Elbadawi,Kamal Mustafa Elhag,Elsheikh Mahgoub,Hisham N. Altayb,Muzamil Mahdi Abdel Hamid
Antimicrobial resistance (AMR) constitutes a continuously growing threat to the effective treatment of microbial infections. AMR surveillance is key for determining the prevalence patterns of AMR, which is fundamental for the development of national and international treatment strategies. Most of the available surveillance data....
Study of Antibodies to Cytolethal Distending Toxin B (CdtB) and Antibodies to Vinculin in Patients with Irritable Bowel Syndrome
Maysaa El Sayed Zaki,Dina Elhammady,Mona Foda Salama,Mostafa Abdelsalam,Asmaa Osama Bakr Osman
Irritable bowel syndrome (IBS) is a common gut disorder that affects approximately 11% of the global population.. The Rome working team recommended classifying subjects with IBS into different sub-groups depending on their bowel habits changes predominance. The IBS sub-groups included IBS with constipation (IBS-C), IBS with diar....
Postoperative pain and antibacterial effect of 980 nm diode laser versus conventional endodontic treatment in necrotic teeth with chronic periapical lesions: A randomized control trial
Dina A. Morsy,Maged Negm,Alaa Diab,Geraldine Ahmed
The therapeutic goal of endodontic treatment in cases of necrotic teeth with chronic periapical lesions is the creation of a sterile, bacteria-free environment in the tooth and at the apex, including the periodontal tissue and the surrounding apical bonen
Invariant death
Steven A. Frank
The coil of a snail’s shell expresses the duality of constraint and process. The logarithmic spiral of growth constrains overall form. Particular snails modulate the process of shell deposition, varying the parameters of the logarithmic spiral. To interpret the variety of snail shells, one must recognize the interplay between br....
The relationships between pancreatic T2* values and pancreatic iron loading with cardiac dysfunctions, hepatic and cardiac iron siderosis among Egyptian children and young adults with β-thalassaemia major and sickle cell disease: a cross-sectional study
Khaled Salama,Amina Abdelsalam,Hadeel Seif Eldin,Eman Youness,Yasmeen Selim,Christine Salama,Gehad Hassanein,Mohamed Samir,Hanan Zekri
The hallmark of chronic hemolytic anemias (CHAs) is premature destruction of erythrocytes. Consequently, it is important to detect silent cardiac dysfunction early before the development of symptomatic heart diseasen
Evaluation of controlled type II diabetics ascending and descending a ramp surface at an imposed speed: A case-control study
Martin G. Rosario,Elizabeth Orozco,Nairoby Babilonia,Greisy Tellez,Francheska Mojica,Maryvi Gonzalez-Sola,Flavia Bayron
Significant gait and balance deficits have been found in persons with type two diabetes mellitus (DMII) compared to individuals without DMII (. As a result of having gait and balance deficits, Dingwell. However, recent evidence suggests that similar gait and balance deficits can be found in individuals with DMII without PN (. In....
Measuring the effectiveness of maternal delivery services: A cross-sectional and qualitative study of perinatal mortality in six primary referral hospitals, Kenya
Richard Ayah,Dismas Ongore,Alfred T.O. Agwanda
The hospital sector represents approximately 45–69% of government health expenditure in sub-Saharan Africa and the effective performance of the sub-sector is therefore critical to overall health system goal achievement. In Kenya, overall health status is measured by indicators including life expectancy, and under-five and matern....
Case Report: Coronary artery stent infection with mycotic aneurysm secondary to tricuspid valve infective endocarditis
Mejdi Ben Messaoud,Nidhal Bouchahda,Marouane Mahjoub,Badii Hmida,Zohra Dridi,Habib Gamra
Infectious complications following percutaneous cardiac interventions are known but not very common. Coronary stent implantation is associated with complications, though rare, such as stent infection or coronary aneurysms resulting from several mechanisms, and needing special investigations for their diagnosis and management. We....
Overuse of prophylactic antibiotics for elective caesarean delivery in Medani Hospital, Sudan
Tahani E. Abbas,Ishag Adam,Elhassan M. Elhassan,Imad Eldin M. Tag Eldin,Mirgani Abdel Rahman
Cesarean delivery (CD) is a procedure mainly performed to save the lives of mother and child to ensure a healthy outcome when normal vaginal delivery is not possible. It is the most common major surgical procedure performed worldwide (. The Cochrane Database of Systematic Reviews has reported that antibiotic prophylaxis has redu....
Maternal age and intracytoplasmic sperm injection outcome in infertile couples at Khartoum, Sudan
Mohamed Ahmed,Osama Shareef,Ishag Adam,Duria Rayis
fertilization (IVF) is recognized as the last treatment option for infertile couples who want biological children, and has been widely accepted as the most important and efficient treatment for infertility (n
The relationship between Helicobacter pylori infection and intestinal parasites in individuals from Khartoum state, Sudan: a case-control study
Yasir Yousif Abd Elbagi,Ahmed Bakheet Abd Alla,Mohammed Baha Eldin Saad
Among the most common diseases in the world are intestinal parasite infections; an estimated 3.5 billion people are affected, and 450 million people are infected (. Health impacts differ with age: the small intestinal protozoa. can be easily identified in all microbiology laboratories using simple techniques (n
Case Report: Root resorption caused after pulp death of adjacent primary molar
Maha M. Azab,Dalia M. Moheb,Osama I. El Shahawy
Root resorption is the physiologic or pathologic loss of dentin and/or cementum and/or bone. Primary teeth can go through either type, but other than resorption during the shedding process resorption is considered pathologic. Inflammatory root resorption is not a rare finding in the pediatric community, with spread of infection....
Knowledge of infection prevention and control practices among health care workers caring for patients with suspected or confirmed COVID-19: a cross-sectional study
Eman H Elsebaie,Amany A Salem,Amal S Sedrak,Ahmed Ayad,Sahar A Ahmed,Bassante A El Razik,Noha M Abu bakr Elsaid
A pandemic of SARS-CoV2 was proclaimed on March 11, 2020.. Healthcare facilities associated infections is considered a serious public health problem.. According to the COVID-19 Situation Report by World Health Organization (WHO) 82, 52 countries had identified a total of 22,073 health care workers (HCWs) had caught COVID-19.. Ac....