Characterization of potential drug targeting folate transporter proteins from Eukaryotic Pathogens
Mofolusho O. Falade,Benson Otarigho
A heterogeneous diversity of eukaryotic pathogens is responsible for the most economically important diseases of humans and animals. A metabolic pathway that has been exploited considerably for the development of drugs is the folate biosynthetic pathway. In addition to the folate biosynthesis pathway, proteins that mediate trans....
Targeted pharmacotherapy after somatic cancer mutation screening
Thomas M. Polasek,Karen Ambler,Hamish S. Scott,Michael J. Sorich,Peter A. Kaub,Andrew Rowland,Michael D. Wiese,Ganessan Kichenadasse
Over the last 20 years the molecular profiles of many solid tumours have been characterised. The discovery of specific variants in critical proteins that influence cancer pathogenesis has seen the development of ‘targeted pharmacotherapy’ – drugs that selectively inhibit unique molecular targets in tumour cells. Compared to trad....
Evaluation of post-bleaching hypersensitivity using desensitizing agent before and /or after in-office bleaching: A randomized clinical trial.
Silvia Sabry Tawfik,Mohamed Adel Ezzat Khairy,Maha Abd Elsalam ElBaz,Maha Ebrahim Mohamed El korashy
In-office bleaching permits close professional control, prevents material ingestion, reduces the total treatment time, and has the potential for quick results, improving patient satisfaction. For this reason, a desensitizing agent is used to decrease the tooth sensitivity that patients experience. The mechanism of action of pota....
Magnitude of parasitic infections and associated factors among pregnant women at health facilities in Hawassa, Southern Ethiopia
Demelash Wachamo,Fisseha Bonja,Bamlaku Tadege,Siraj Hussen
Intestinal parasitic infections, mainly soil-transmitted helminths, and water-related parasitic diseases are is the common problem during pregnancy in low- and middle-income countries (LMICs). Those in developing countries are more likely to suffer from IPIs due to a lack of resources, poverty, low literacy rates, lack of safe d....
Assessment of cardiovascular risk in post-menopausal women in Ghana
Justice Afrifa,Felix A. Botchway,Yeboah Kwaku Opoku,Joyce Badohu,Henrietta Ekua Ocran,Kwame Kumi Asare,Samuel Essien-Baidoo
Menopause is a permanent physiological state with cessation of menstruation attributable to the loss of ovarian function and reduction in the production of estrogen. Cardiovascular diseases (CVD) are the major cause of death among post-menopausal women. Current data have shown that Castelli risk index I and II which are estimate....
Teenage pregnancy in Nigeria: professional nurses and educators’ perspectives
Oluwaseyi Abiodun Akpor,Gloria Thupayagale-Tshweneagae
According to Kanku and Mash. Regardless of the various teenage pregnancy prevention strategies and programmes that have been established, teenage pregnancies and birth-rates are still outrageously high. High incidence of teenage pregnancy is a global phenomenon. One of the most important obligations that a country can make in or....
Strong association between higher-risk sex and HIV prevalence at the regional level: an ecological study of 27 sub-Saharan African countries
Chris R. Kenyon,Jozefien Buyze,Ilan S. Schwartz
DHS - Demographic Health Survey. PC - Principal components. PCA - Principal components analysis. STI - Sexually transmitted infection
Characterization of Panton–Valentine leukocidin-positive Staphylococcus aureus from skin and soft tissue infections and wounds in Nigeria: a cross-sectional study
Olayemi O. Ayepola,Nurudeen A. Olasupo,Louis O. Egwari,Frieder Schaumburg
is an important human pathogen that causes significant hospital and community acquired infectionsn
Metachronous or synchronous male breast and prostate cancers a duality to lookout for.
Alain Mwamba Mukendi,Eunice Van Den Berg,Sugeshnee Pather,Rushen Siva Padayachee
Prostate cancer is one of the leading causes of male cancer death. Male breast cancer is very rare, and comprises only about 1% of all breast cancers. Men with a family history of breast or prostate cancer have elevated prostate cancer risks, including risk of very aggressive disease. We present 2 cases of primary prostate and p....
Association between intermittent administration of parathyroid hormone 1-34 and ectopic calcification in rats
Israa Ahmed Radwan,Nahed Sedky Korany,Bassant Adel Ezzat
Ectopic calcification is pathologic deposition of minerals within soft tissues as dental pulp or periodontal ligaments (PDL). Parathyroid hormone (PTH) is a naturally occurring hormone, important for calcium homeostasisn
Publications in PubMed on Ebola and the 2014 outbreak
Andrea Ballabeni,Andrea Boggio
The Ebola outbreak that has affected West Africa for over a year has captured the attention of audiences throughout the world. Much has been said and written about this tragic event in the popular media as well as in scientific journalsn
Closing the communication gap in neonatal inter-hospital transfer: a neonatal referral form for resource-limited settings - a modified e-Delphi-consensus study
Oscar Mwizerwa,Christian Umuhoza,Mark H. Corden,Tom Lissauer,Peter Thomas Cartledge
Globally, neonatal mortality fell to 19 per 1000 live births in 2015 with the aim to reduce neonatal mortality to less than 12 per 1000 live births by 2030.. A specialised transport system for neonates can mitigate against these risks.n
Risk factors for major external structural birth defects among children in Kiambu County, Kenya: a case-control study
George N. Agot,Marshal M. Mweu,Joseph K. Wang'ombe
Worldwide, an estimated 7.9 million children are born every year with a birth defect of which approximately 3.3 million die before age five and around 3.2 million could be physically disabled for life. Organogenesis occurs in the first eight weeks of gestation; however, approximately half of pregnancies are usually unplanned/uni....
Accuracy of linear measurements obtained from stitched cone beam computed tomography images versus direct skull measurements
Doaa Ahmed Fouad Hamed,Mostafa Mohamed El Dawlatly,Sahar Hosny El Dessouky,Reham Mohamed Hamdy
The use of cone beam computed tomography (CBCT) machines in dentistry started in the second half of the 1990s. In the field of orthodontics, analysis of cephalometric radiographs requires accurate identification of specific landmarks for precise measurements between these landmarks. In order to compensate for this shortcoming, s....
The efficacy of disinfectants on abattoirs’ Candida albicans isolates in Niger Delta region
Oluwayemisi A Olorode,G Chijioke Okpokwasli
is a diploid fungus that grows both as yeast and filamentous cells and a causal agent of opportunistic oral and genital infections in human. Calderone (2002) stated that. According to Sheehan n
Frequencies of gastrointestinal parasites among students of primary school in Al Kalakla Locality, Khartoum State, Sudan: a cross-sectional study
Hala Abdalazim Hassan,Ahmed Bakheet Abd Alla,Tayseer Elamin Mohamed Elfaki,Mohammed Baha Eldin Ahmed Saad
Intestinal parasites, particularly in tropical and subtropical areas, are a significant health issuen
COVID-19 Vaccine Storage, Preparation and Administration
Dr. Maureen Akolo
This course is about vaccine storage, preparation and administration
Notification and Voluntary Reporting in Sexual Health
Tom Yates, Jackie Cassell, Sophie Herbert, Daniel Trotman
This session will introduce you to the regulations for the notification and control of communicable disease in the UK; the role of the health protection services; the doctor's duty to report notifiable diseases; and what this means in practice for the genitourinary medicine clinic and other sexual health services.
Stroke Journey - Acute to Rehab
Skye Coote and Renee McMillan
Stroke care is time-based and earlier treatment leads to better patient outcomes, however in ever increasingly busy emergency departments, timely treatment for stroke continues to face challenges which can be detrimental to our patients. Learn about key strategies and ways in which acute stroke care in Australia can be im....
Study Designs in Clinical Research
Dr. Anthony Ajayi and Prof. Gunturu Revathi
Study Designs in Clinical Research
Electronic Fetal Heart Rate (EFHR) Monitoring
Justine Carla Baron, MNur, BHon
Describe the advantages and disadvantages of CTGs. Describe fetal response to hypoxia. Define the terms related to fetal heart rate monitoring. Interpret a cardiotocograph. Describe the management of abnormal fetal heart rate patterns.
The Importance of Assessment
Dr Rebecca Threatt DNP, RN, CHSE
Physical assessment is a critical element in providing quality patient care in all patients. It is important to know the baseline of the patient's condition (what is normal and what is not normal). It will help to find out what the main concerns are, what is wrong, help to locate specific pains or issues and then to make the cor....
HIV and TB prescriptions, people and problems
Dr Melanie Collins
This webinar will discuss topics on HIV and Tuberculosis – Prescriptions, People and Problems
National Clinical Guidelines on Management of Diabetes Mellitus
Ministry of Health, Kenya
This course provides a comprehensive guide for the management of diabetes mellitus, tailored to various levels of healthcare. It emphasizes patient-centered care, evidence-based interventions, and a multidisciplinary approach to screening, diagnosis, and treatment. The course covers a wide range of topics, including epidemiology....