Virtual-screening workflow tutorials and prospective results from the Teach-Discover-Treat competition 2014 against malaria
Sereina Riniker,Gregory A. Landrum,Floriane Montanari,Santiago D. Villalba,Julie Maier,Johanna M. Jansen,W. Patrick Walters,Anang A. Shelat
Teach-Discover-Treat (TDT) is an initiative that aims to provide high-quality tutorials of important tasks in computer-aided drug discovery, in order to impact education and drug discovery for neglected diseases. Malaria is caused in humans by several species of the protozoan parasite. Challenge 1 of the 2014 TDT competition inv....
Evaluation of portal pressure by doppler ultrasound in patients with cirrhosis before and after simvastatin administration – a randomized controlled trial
Nadia Elwan,Raafat Salah,Manal Hamisa,Ebtsam Shady,Nehad Hawash,Sherief Abd-Elsalam
Liver cirrhosis is considered to be the most common cause of portal hypertension (PHT). The ideal hypotensive drug for PHT should decrease portal pressure by lowering intrahepatic vascular resistance while maintaining or increasing hepatic blood flow. Currently, the available therapies for PHT are based on the use of β-adrenergi....
Drug Utilization Evaluation of Vancomycin among Patients in Jafar Ibn Auf Pediatric Hospital, 2018
Tagwa A. M. Salih,Bashir A. Yousef,Mohamed A. M. Salih,Khalid S. Eltom
The majority of admitted inpatients are given antimicrobials as therapy or prophylaxis during their hospitalization. It has been shown that at least 50% of antimicrobial prescriptions are unnecessary. Antimicrobial over prescription increases the costs of health care, increases super-infection due to antimicrobial-resistant bact....
Streptococcus pneumoniae serotype specific anti-microbial susceptibility profiles among PCV-10 vaccinated and unvaccinated children attending Gertrude’s Children’s Hospital: a cross-sectional study
Michael Walekhwa,Margaret Muturi,Eucharia Kenya,Beatrice Kabera
Globally, there is a growing concern over the burden of antimicrobial resistance (AMR) because it is presently estimated to account for more than 700,000 deaths per year worldwide (. Diverse forms of pneumococcal disease are rated among the highest vaccine preventable etiologies of child morbidity and mortality globally (. Overt....
Post-orgasmic illness syndrome: a case report
Abdalla M Attia,Hossam A Yasien,Magda H Al-Ziny
Post-orgasmic illness syndrome (POIS) was first reported and named by Waldinger and Schweitzer in 2002. To the best of our knowledge, aside from two cases reported by Waldinger and Schweitzer. POIS appears to be principally a male orgasmic disorder, as most of the reported cases are males. Its manifestations start within seconds....
Influenza virus infection of well-differentiated human airway epithelial cells by infectious aerosols: insights into the earliest stages of infection
Claire M. Smith,Dani Do Hyang Lee,Hemant Kulkarni,Priya Radhakrishnan,Robert Hirst,Andrew Easton,Chris O'Callaghan
Influenza viruses cause annual epidemics that are associated with considerable morbidity and mortality. We have previously used human ciliated epithelial cells in culture to evaluate the effects of bacteria and viruses. The primary aim of this study was to evaluate the effect of influenza virus infection, either by aerosol or by....
Female circumcision: Limiting the harm
Mohamed Kandil
Female genital cutting/mutilation (FGC/M), or circumcision as it was previously described. The legislations enacted in most countries to ban FGC had minimal effect on its prevalencen
Hyperthermic intraperitoneal chemoperfusion with high dose oxaliplatin: Influence of perfusion temperature on postoperative outcome and survival
Johanna Verhulst
The research data that were used by the author are part of a study n
Targeted pharmacotherapy after somatic cancer mutation screening
Thomas M. Polasek,Karen Ambler,Hamish S. Scott,Michael J. Sorich,Peter A. Kaub,Andrew Rowland,Michael D. Wiese,Ganessan Kichenadasse
Over the last 20 years the molecular profiles of many solid tumours have been characterised. The discovery of specific variants in critical proteins that influence cancer pathogenesis has seen the development of ‘targeted pharmacotherapy’ – drugs that selectively inhibit unique molecular targets in tumour cells. Compared to trad....
Assessment of cardiovascular risk in post-menopausal women in Ghana
Justice Afrifa,Felix A. Botchway,Yeboah Kwaku Opoku,Joyce Badohu,Henrietta Ekua Ocran,Kwame Kumi Asare,Samuel Essien-Baidoo
Menopause is a permanent physiological state with cessation of menstruation attributable to the loss of ovarian function and reduction in the production of estrogen. Cardiovascular diseases (CVD) are the major cause of death among post-menopausal women. Current data have shown that Castelli risk index I and II which are estimate....
Magnitude of parasitic infections and associated factors among pregnant women at health facilities in Hawassa, Southern Ethiopia
Demelash Wachamo,Fisseha Bonja,Bamlaku Tadege,Siraj Hussen
Intestinal parasitic infections, mainly soil-transmitted helminths, and water-related parasitic diseases are is the common problem during pregnancy in low- and middle-income countries (LMICs). Those in developing countries are more likely to suffer from IPIs due to a lack of resources, poverty, low literacy rates, lack of safe d....
Characterization of potential drug targeting folate transporter proteins from Eukaryotic Pathogens
Mofolusho O. Falade,Benson Otarigho
A heterogeneous diversity of eukaryotic pathogens is responsible for the most economically important diseases of humans and animals. A metabolic pathway that has been exploited considerably for the development of drugs is the folate biosynthetic pathway. In addition to the folate biosynthesis pathway, proteins that mediate trans....
Evaluation of post-bleaching hypersensitivity using desensitizing agent before and /or after in-office bleaching: A randomized clinical trial.
Silvia Sabry Tawfik,Mohamed Adel Ezzat Khairy,Maha Abd Elsalam ElBaz,Maha Ebrahim Mohamed El korashy
In-office bleaching permits close professional control, prevents material ingestion, reduces the total treatment time, and has the potential for quick results, improving patient satisfaction. For this reason, a desensitizing agent is used to decrease the tooth sensitivity that patients experience. The mechanism of action of pota....
Characterization of Panton–Valentine leukocidin-positive Staphylococcus aureus from skin and soft tissue infections and wounds in Nigeria: a cross-sectional study
Olayemi O. Ayepola,Nurudeen A. Olasupo,Louis O. Egwari,Frieder Schaumburg
is an important human pathogen that causes significant hospital and community acquired infectionsn
Strong association between higher-risk sex and HIV prevalence at the regional level: an ecological study of 27 sub-Saharan African countries
Chris R. Kenyon,Jozefien Buyze,Ilan S. Schwartz
DHS - Demographic Health Survey. PC - Principal components. PCA - Principal components analysis. STI - Sexually transmitted infection
Metachronous or synchronous male breast and prostate cancers a duality to lookout for.
Alain Mwamba Mukendi,Eunice Van Den Berg,Sugeshnee Pather,Rushen Siva Padayachee
Prostate cancer is one of the leading causes of male cancer death. Male breast cancer is very rare, and comprises only about 1% of all breast cancers. Men with a family history of breast or prostate cancer have elevated prostate cancer risks, including risk of very aggressive disease. We present 2 cases of primary prostate and p....
Teenage pregnancy in Nigeria: professional nurses and educators’ perspectives
Oluwaseyi Abiodun Akpor,Gloria Thupayagale-Tshweneagae
According to Kanku and Mash. Regardless of the various teenage pregnancy prevention strategies and programmes that have been established, teenage pregnancies and birth-rates are still outrageously high. High incidence of teenage pregnancy is a global phenomenon. One of the most important obligations that a country can make in or....
Closing the communication gap in neonatal inter-hospital transfer: a neonatal referral form for resource-limited settings - a modified e-Delphi-consensus study
Oscar Mwizerwa,Christian Umuhoza,Mark H. Corden,Tom Lissauer,Peter Thomas Cartledge
Globally, neonatal mortality fell to 19 per 1000 live births in 2015 with the aim to reduce neonatal mortality to less than 12 per 1000 live births by 2030.. A specialised transport system for neonates can mitigate against these risks.n
Risk factors for major external structural birth defects among children in Kiambu County, Kenya: a case-control study
George N. Agot,Marshal M. Mweu,Joseph K. Wang'ombe
Worldwide, an estimated 7.9 million children are born every year with a birth defect of which approximately 3.3 million die before age five and around 3.2 million could be physically disabled for life. Organogenesis occurs in the first eight weeks of gestation; however, approximately half of pregnancies are usually unplanned/uni....
Accuracy of linear measurements obtained from stitched cone beam computed tomography images versus direct skull measurements
Doaa Ahmed Fouad Hamed,Mostafa Mohamed El Dawlatly,Sahar Hosny El Dessouky,Reham Mohamed Hamdy
The use of cone beam computed tomography (CBCT) machines in dentistry started in the second half of the 1990s. In the field of orthodontics, analysis of cephalometric radiographs requires accurate identification of specific landmarks for precise measurements between these landmarks. In order to compensate for this shortcoming, s....
Association between intermittent administration of parathyroid hormone 1-34 and ectopic calcification in rats
Israa Ahmed Radwan,Nahed Sedky Korany,Bassant Adel Ezzat
Ectopic calcification is pathologic deposition of minerals within soft tissues as dental pulp or periodontal ligaments (PDL). Parathyroid hormone (PTH) is a naturally occurring hormone, important for calcium homeostasisn
Frequencies of gastrointestinal parasites among students of primary school in Al Kalakla Locality, Khartoum State, Sudan: a cross-sectional study
Hala Abdalazim Hassan,Ahmed Bakheet Abd Alla,Tayseer Elamin Mohamed Elfaki,Mohammed Baha Eldin Ahmed Saad
Intestinal parasites, particularly in tropical and subtropical areas, are a significant health issuen
Case Report: Aortitis associated with rheumatoid arthritis: A challenging rheumatoid vasculitis presentation
Zeineb Teyeb,Mohamed Ben Salah,Lobna Kharrat,Imen Abdellali,Taieb Jomni,Mohamed Hedi Douggui
Rheumatoid arthritis (RA) is a connective tissue disease predominantly affecting the joints. Extra-articular manifestations develop in up to 40% of casesn
The efficacy of disinfectants on abattoirs’ Candida albicans isolates in Niger Delta region
Oluwayemisi A Olorode,G Chijioke Okpokwasli
is a diploid fungus that grows both as yeast and filamentous cells and a causal agent of opportunistic oral and genital infections in human. Calderone (2002) stated that. According to Sheehan n
Publications in PubMed on Ebola and the 2014 outbreak
Andrea Ballabeni,Andrea Boggio
The Ebola outbreak that has affected West Africa for over a year has captured the attention of audiences throughout the world. Much has been said and written about this tragic event in the popular media as well as in scientific journalsn