Targeted pharmacotherapy after somatic cancer mutation screening
Thomas M. Polasek,Karen Ambler,Hamish S. Scott,Michael J. Sorich,Peter A. Kaub,Andrew Rowland,Michael D. Wiese,Ganessan Kichenadasse
Over the last 20 years the molecular profiles of many solid tumours have been characterised. The discovery of specific variants in critical proteins that influence cancer pathogenesis has seen the development of ‘targeted pharmacotherapy’ – drugs that selectively inhibit unique molecular targets in tumour cells. Compared to trad....
Assessment of cardiovascular risk in post-menopausal women in Ghana
Justice Afrifa,Felix A. Botchway,Yeboah Kwaku Opoku,Joyce Badohu,Henrietta Ekua Ocran,Kwame Kumi Asare,Samuel Essien-Baidoo
Menopause is a permanent physiological state with cessation of menstruation attributable to the loss of ovarian function and reduction in the production of estrogen. Cardiovascular diseases (CVD) are the major cause of death among post-menopausal women. Current data have shown that Castelli risk index I and II which are estimate....
Magnitude of parasitic infections and associated factors among pregnant women at health facilities in Hawassa, Southern Ethiopia
Demelash Wachamo,Fisseha Bonja,Bamlaku Tadege,Siraj Hussen
Intestinal parasitic infections, mainly soil-transmitted helminths, and water-related parasitic diseases are is the common problem during pregnancy in low- and middle-income countries (LMICs). Those in developing countries are more likely to suffer from IPIs due to a lack of resources, poverty, low literacy rates, lack of safe d....
Characterization of potential drug targeting folate transporter proteins from Eukaryotic Pathogens
Mofolusho O. Falade,Benson Otarigho
A heterogeneous diversity of eukaryotic pathogens is responsible for the most economically important diseases of humans and animals. A metabolic pathway that has been exploited considerably for the development of drugs is the folate biosynthetic pathway. In addition to the folate biosynthesis pathway, proteins that mediate trans....
Evaluation of post-bleaching hypersensitivity using desensitizing agent before and /or after in-office bleaching: A randomized clinical trial.
Silvia Sabry Tawfik,Mohamed Adel Ezzat Khairy,Maha Abd Elsalam ElBaz,Maha Ebrahim Mohamed El korashy
In-office bleaching permits close professional control, prevents material ingestion, reduces the total treatment time, and has the potential for quick results, improving patient satisfaction. For this reason, a desensitizing agent is used to decrease the tooth sensitivity that patients experience. The mechanism of action of pota....
Characterization of Panton–Valentine leukocidin-positive Staphylococcus aureus from skin and soft tissue infections and wounds in Nigeria: a cross-sectional study
Olayemi O. Ayepola,Nurudeen A. Olasupo,Louis O. Egwari,Frieder Schaumburg
is an important human pathogen that causes significant hospital and community acquired infectionsn
Strong association between higher-risk sex and HIV prevalence at the regional level: an ecological study of 27 sub-Saharan African countries
Chris R. Kenyon,Jozefien Buyze,Ilan S. Schwartz
DHS - Demographic Health Survey. PC - Principal components. PCA - Principal components analysis. STI - Sexually transmitted infection
Metachronous or synchronous male breast and prostate cancers a duality to lookout for.
Alain Mwamba Mukendi,Eunice Van Den Berg,Sugeshnee Pather,Rushen Siva Padayachee
Prostate cancer is one of the leading causes of male cancer death. Male breast cancer is very rare, and comprises only about 1% of all breast cancers. Men with a family history of breast or prostate cancer have elevated prostate cancer risks, including risk of very aggressive disease. We present 2 cases of primary prostate and p....
Teenage pregnancy in Nigeria: professional nurses and educators’ perspectives
Oluwaseyi Abiodun Akpor,Gloria Thupayagale-Tshweneagae
According to Kanku and Mash. Regardless of the various teenage pregnancy prevention strategies and programmes that have been established, teenage pregnancies and birth-rates are still outrageously high. High incidence of teenage pregnancy is a global phenomenon. One of the most important obligations that a country can make in or....
Closing the communication gap in neonatal inter-hospital transfer: a neonatal referral form for resource-limited settings - a modified e-Delphi-consensus study
Oscar Mwizerwa,Christian Umuhoza,Mark H. Corden,Tom Lissauer,Peter Thomas Cartledge
Globally, neonatal mortality fell to 19 per 1000 live births in 2015 with the aim to reduce neonatal mortality to less than 12 per 1000 live births by 2030.. A specialised transport system for neonates can mitigate against these risks.n
Risk factors for major external structural birth defects among children in Kiambu County, Kenya: a case-control study
George N. Agot,Marshal M. Mweu,Joseph K. Wang'ombe
Worldwide, an estimated 7.9 million children are born every year with a birth defect of which approximately 3.3 million die before age five and around 3.2 million could be physically disabled for life. Organogenesis occurs in the first eight weeks of gestation; however, approximately half of pregnancies are usually unplanned/uni....
Accuracy of linear measurements obtained from stitched cone beam computed tomography images versus direct skull measurements
Doaa Ahmed Fouad Hamed,Mostafa Mohamed El Dawlatly,Sahar Hosny El Dessouky,Reham Mohamed Hamdy
The use of cone beam computed tomography (CBCT) machines in dentistry started in the second half of the 1990s. In the field of orthodontics, analysis of cephalometric radiographs requires accurate identification of specific landmarks for precise measurements between these landmarks. In order to compensate for this shortcoming, s....
Association between intermittent administration of parathyroid hormone 1-34 and ectopic calcification in rats
Israa Ahmed Radwan,Nahed Sedky Korany,Bassant Adel Ezzat
Ectopic calcification is pathologic deposition of minerals within soft tissues as dental pulp or periodontal ligaments (PDL). Parathyroid hormone (PTH) is a naturally occurring hormone, important for calcium homeostasisn
Frequencies of gastrointestinal parasites among students of primary school in Al Kalakla Locality, Khartoum State, Sudan: a cross-sectional study
Hala Abdalazim Hassan,Ahmed Bakheet Abd Alla,Tayseer Elamin Mohamed Elfaki,Mohammed Baha Eldin Ahmed Saad
Intestinal parasites, particularly in tropical and subtropical areas, are a significant health issuen
Case Report: Aortitis associated with rheumatoid arthritis: A challenging rheumatoid vasculitis presentation
Zeineb Teyeb,Mohamed Ben Salah,Lobna Kharrat,Imen Abdellali,Taieb Jomni,Mohamed Hedi Douggui
Rheumatoid arthritis (RA) is a connective tissue disease predominantly affecting the joints. Extra-articular manifestations develop in up to 40% of casesn
The efficacy of disinfectants on abattoirs’ Candida albicans isolates in Niger Delta region
Oluwayemisi A Olorode,G Chijioke Okpokwasli
is a diploid fungus that grows both as yeast and filamentous cells and a causal agent of opportunistic oral and genital infections in human. Calderone (2002) stated that. According to Sheehan n
Publications in PubMed on Ebola and the 2014 outbreak
Andrea Ballabeni,Andrea Boggio
The Ebola outbreak that has affected West Africa for over a year has captured the attention of audiences throughout the world. Much has been said and written about this tragic event in the popular media as well as in scientific journalsn
Experiences of the International In-Training Examination (I-ITE) by Rwandan pediatric residents – a mixed-methods description of candidate feedback
Peter Thomas Cartledge,Christian Umuhoza,Natalie McCall
ABP: American Board of Pediatrics; CBA: computer-based assessment; HRH: Human Resources for Health; I-ITE: International In-Training Examination; IRB: institutional review board; ITE: In-Training Examination; LMICs: low- and middle-income countries; MCQs: multiple-choice questions; PBA : paper-based assessments; PI: Principal In....
A Journey of Hope: giving research participants a voice to share their experiences and improve community engagement around advanced HIV disease in Uganda
Fiona V. Cresswell,John Kasibante,Emily M. Martyn,Lillian Tugume,Gavin Stead,Kenneth Ssembambulidde,Morris K. Rutakingirwa,Enock Kagimu,Laura Nsangi,Carol Namuju,Jane F. Ndyetukira,Cynthia Ahimbisibwe,Florence Kugonza,Alisat Sadiq,Alice Namudde,Joanna Dob
Substantial progress has been made in the treatment and prevention of HIV in the last decade thanks largely to the widespread roll out of antiretroviral treatment (ART) and recommendation to treat all people living with HIV (PLHIV) regardless of CD4 cell count. The ambitious UNAIDS “90-90-90” target states that, by 2020, 90% of....
The Collaborative African Genomics Network (CAfGEN): Applying Genomic technologies to probe host factors important to the progression of HIV and HIV-tuberculosis infection in sub-Saharan Africa
Gerald Mboowa,Savannah Mwesigwa,Eric Katagirya,Gaone Retshabile,Busisiwe C. Mlotshwa,Lesedi Williams,Adeodata Kekitiinwa,David Kateete,Eddie Wampande,Misaki Wayengera,Betty Nsangi Kintu,Grace P. Kisitu,Samuel Kyobe,Chester W. Brown,Neil A. Hanchard
In 2011, a group of scientists came together and conceived the white paper “. The clinically important research goals of. The completion of the Human Genome Project in 2003 catapulted efforts to use genomics to enhance our understanding of human diseases. Genetics and genomics have a particularly important role to play in biomed....
Evaluating community’s knowledge on integrated malaria, schistosomiasis and soil transmitted helminth (STH) infections in a Lake Victoria island, Kenya: A mixed method approach
Jesse Gitaka,Peter Mwaura,Kevin Oware,James Kongere,Job Wasonga,Sultani Matendechero
In most developing countries, the problem of malaria, schistosomiasis and soil transmitted helminth (STH) poses a considerable challenge and contributes to the high burden of diseases. These parasitic infections, grouped under Neglected Tropical Diseases (NTDs) including malaria have been found to affect millions of people in su....
Case Report: A forty year-survivor of Tetralogy of Fallot with pulmonary atresia and chronic pediatric shunt thrombosis; findings from cardiac CT scan
Asma Achour,Walid Mnari,Mabrouk Abdelali,Ahmed Zrig,Ahmed Miladi,Mejdi Ben Messaoud,Badii Hmida,Mezri Maatouk
Tetralogy of Fallot (TOF) is the most frequent form of cyanotic congenital heart disease. Only a few patients come of age without surgical intervention mainly in the extreme form with pulmonary atresian
Case Report: Recurrent retinal vein occlusion as the first clinical manifestation of systemic lupus erythematosus in a male patient
Marwa Ben Brahim,Sondes Arfa,Fadia Boubaker,Jihen Chelly,Wafa Ammari,Sonia Hammami,Fatma Arbi,Olfa Berriche
Retinal vein occlusion (RVO) is a common retinal vascular disorder that, if left untreated, can lead to vision lossn
Zika virus reservoirs: Implications for transmission, future outbreaks, drug and vaccine development
Raj Kalkeri,Krishna K. Murthy
After the recent outbreak of Zika virus (ZIKV) infection in Brazil and other countries, multiple studies have been published regarding various tissue reservoirs, including the eyes, nervous system, genitourinary tracts and placenta (n
Impact of 1.5 oC and 2 oC global warming scenarios on malaria transmission in East Africa
Obed Matundura Ogega,Moses Alobo
Malaria is an illness caused by. Malaria transmission is affected by, among other things, climatic factors such as temperature, rainfall, and humidity that influence the abundance and survival of mosquitoes (n