Understanding Ethical, Legal and Societal Issues (ELSIs) in Human Biobanking and Genomics for Research and Healthcare in Zimbabwe: The Genomics Inheritance Law Ethics and Society (GILES) initiative
Alice Matimba,Andrew Chimatira,Oppah Kuguyo,James January,Zivayi Mupambireyi,Bazondlile Marimbe-Dube,Vasco Chikwasha,Zibusiso Nyati-Jokomo,Shamiso Muteti,Pedzisayi Mangezvo,Abigail Kangwende,Alfred Chingono,Midion Chidzonga,Jonathan Gandari,James Hakim,Ku
Biobanks of human biospecimen collections are key resources for understanding individual and population diversity, and are integral to healthcare research, medical care, and drug discoveryn
African Pharmacogenomics Consortium: Consolidating pharmacogenomics knowledge, capacity development and translation in Africa
Collet Dandara,Collen Masimirembwa,Yosr Z. Haffani,Bernhards Ogutu,Jenniffer Mabuka,Eleni Aklillu,Oluseye Bolaji
The views expressed in this article are those of the authors. Publication in AAS Open Research does not imply endorsement by the AAS.
Preliminary evaluation of a Trypanosoma brucei FG-GAP repeat containing protein of mitochondrial localization
Monica Namyanja,Zhi-Shen Xu,Claire Mack Mugasa,Zhao-Rong Lun,Enock Matovu,Zhengjun Chen,George W. Lubega
is a hemoflagellated extracellular protozoan parasite that causes a zoonotic disease known as African Trypanosomiasis. It comprises of three subspecies, namely,. In the GeneDB and TritrypDB genomic databases, n
Characterization of culturable airborne bacteria and antibiotic susceptibility profiles of indoor and immediate-outdoor environments of a research institute in Ghana
Isawumi Abiola,Adiza Abass,Samuel Duodu,Lydia Mosi
Quality of air, especially in indoor environments where people spend 80–95% of their lives is of significant health importance. Bioaerosols, mostly bacterial and fungal spores are actively living complex particles that have been associated with contamination of indoor air. Several species of microorganisms have been isolated acr....
“We shall have gone to a higher standard”: Training village heath teams (VHTs) to use a smartphone-guided intervention to link older Ugandans with hypertension and diabetes to care
Joseph Okello Mugisha,Janet Seeley
The number of older adults living with chronic conditions is increasing rapidly in Uganda. Recently, greater attention has been paid to interventions for the prevention and control of chronic conditions in public health care. With the increasing numbers of older adults with chronic conditions, especially hypertension and diabete....
Single dose ceftriaxone and metronidazole versus multiple doses for antibiotic prophylaxis at elective caesarean section in Mulago hospital: A randomized clinical trial
Gideon Alex Mugisa,Paul Kiondo,Imelda Namagembe
The single most important risk factor for postpartum maternal infection is caesarean section. Women undergoing caesarean section have a 5-20-fold greater risk of infection and infectious morbidity compared with a vaginal delivery. (. Provision of single dose or combination broad spectrum intravenous antibiotics 30–60 minutes bef....
Ethical and scientific considerations on the establishment of a controlled human infection model for schistosomiasis in Uganda: report of a stakeholders’ meeting held in Entebbe, Uganda.
Alison M. Elliott,Meta Roestenberg,Anne Wajja,Christopher Opio,Francis Angumya,Moses Adriko,Moses Egesa,Serah Gitome,Joseph Mfutso-Bengo,Philip Bejon,Melissa Kapulu,Zoe Seager,Tom Lutalo,Winfred Badanga Nazziwa,Asuman Muwumuza,Maria Yazdanbakhsh,Pontiano
Effective vaccines have proven extremely useful in the prevention of infectious diseases, but are still lacking for major poverty-related and neglected infections, including helminth infections. The conventional approach to vaccine development, testing efficacy in human subjects in large Phase III trials after safety and immunog....
Predictors of quality of life of older persons in rural Uganda: A cross sectional study
Fred Maniragaba,Betty Kwagala,Emmanuel Bizimungu,Stephen Ojiambo Wandera,James Ntozi
The world is experiencing remarkable and irreversible demographic changes as many people are living longer than ever before. Uganda’s population is largely characterized by young people. Nonetheless, the country’s older population has more than doubled from 686,000 in 1991 to 1,433,596 in 2014 (UBOS 2016. This is attributed to....
Public hospitals’ finance management systems, and accountability mechanisms in the context of decentralized health systems in low- and middle-income countries – A thematic review
Hassan Leli,Osman Addulahi,Benjamin Tsofa
Decentralization, defined as the transfer of power or authority on decision making and resource management, from the central government or body to the local level or subnational unit or institution, has been and continues to be a common health sector reform in many low and middle-income countries (LMICs). Historically, health s....
Dog health and demographic surveillance survey in Western Kenya: Demography and management practices relevant for rabies transmission and control
Emmah N. Kwoba,Philip Kitala,Linus Ochieng,Elkanah Otiang,Robert Ndung’u,Gati Wambura,Katie Hampson,S.M. Thumbi
Rabies kills an estimated 59,000 people annually, mostly in Asia and Africa and among rural populations. In 2014, Kenya launched a National Rabies Elimination Strategic Plan for the elimination of dog-mediated human rabies by the year 2030. Here we describe the design of a dog health and demographic study (dog-HDSS) within an ex....
Developing excellence in biostatistics leadership, training and science in Africa: How the Sub-Saharan Africa Consortium for Advanced Biostatistics (SSACAB) training unites expertise to deliver excellence
Tobias F. Chirwa,Zvifadzo Matsena Zingoni,Pascalia Munyewende,Samuel O. Manda,Henry Mwambi,Ngianga-Bakwin Kandala,Samson Kinyanjui,Taryn Young,Eustasius Musenge,Jupiter Simbeye,Patrick Musonda,Michael Johnson Mahande,Patrick Weke,Nelson Owuor Onyango,Lawr
The views expressed in this article are those of the author(s). Publication in AAS Open Research does not imply endorsement by the AAS.
CATARACT
OCO MUKUYE STEVEN
Cataract is the second leading cause of blindness in the world following uncorrected refractive errors It is estimated that globally there are approximately 100 millions eyes with cataract causing a visual acuity less than 6/60,and this figure is likely to be 3-4times more for cataract causing an acuity of less than 6/18.....
GLAUCOMA SERIES 1
Oco Mukuye Steven and Dr Osama Giasin,
The principal ocular structures concerned with glaucoma are ciliary body, angle of anterior chamber and the aqueous outflow system.
CHILDHOOD BLINDNESS: RETINOPATHY OF PREMATURITY TRAUMA VITAMIN-A DEFICIENCY
Dr Joyce Chan
Eye Health Africa https://eyehealthafrica.org/ This course describes the CHILDHOOD BLINDNESS: RETINOPATHY OF PREMATURITY TRAUMA VITAMIN-A DEFICIENCY
PEARLS IN EXTERNAL EYE DISEASES
Dr Tina Khanam
Eye Health Africa https://eyehealthafrica.org/ This course describes pearls in external eye diseases
Plasmidome AMR screening (PAMRS) workflow: a rapid screening workflow for phenotypic characterization of antibiotic resistance in plasmidomes
Kwabena Obeng Duedu,Joana Qwansima Mends,Reuben Ayivor-Djanie,Priscilla Efua Essandoh,Emmanuel Mawuli Nattah,Jones Gyamfi,Grace Semabia Kpeli
Antibiotic-resistant bacterial infections are a major public health problem. Annually, some estimated 30,000 deaths are recorded in the EU alone. Transformation of bacteria with naked DNA from the extracellular environments is a major contributor to HGT and the spread of ARGs. Some bacterial plasmids have been shown to carry mob....
Analysis of the MUII-plus mentorship programme: reflections of Fellows’ experiences and lessons for other programmes
Irene Andia Biraro,Emmanuella Driciru,Rehema Namaganda,Fiona Luboga,Charles Kato Drago,Anne Wajja,Brenda Okech,Mary Gorrethy N. Mboowa,Raymond Muganyizi,Moses Kizza,Stephen Cose,Victoria Diana Bukirwa,Damalie Nakanjako,Alison M. Elliott
Mentorship in science, research and capacity building programmes is essential to promote personal and professional advancement especially in low- and middle-income countries (LMIC) such as Uganda. The Makerere University Research Training Programme in Infection and Immunity (MUII) programme is a collaborative capacity-building a....
Wear assessment of current aesthetic crowns compared with human enamel after two finishing procedures: In vitro study
Ahmed M. Sha'aban,Gihan A. El Naggar,Rasha Nabil,Mohamed A. Rashad,Yara S. Attia
Wear of teeth is considered one of the most important issues when choosing a dental ceramic. The repeated incidence of veneer chipping with bilayered restorations has prompted the development of monolithic restorations fabricated from high strength ceramicsn
Interfacial microscopic examination and chemical analysis of resin-dentin interface of self-adhering flowable resin composite
Tamer M. Hamdy
Adhesive dentistry has seen a paradigm shift from the invasive to be minimally invasive, due to a revolution in bonding systems. There are great demands for simplified restorative materials. A new self-adhering flowable resin composite (Vertise™ Flow Self-Adhering Flowable Composite, Kerr Dental, USA), was recently introduced on....
Clinical characteristics and predictors of the duration of hospital stay in COVID-19 patients in Jordan
Rami S. Alqassieh,Isam K. Bsisu,Mohammed Qussay Al-Sabbagh,Naser M. El-Hammuri,Moh’d A. Yousef,Mohammad A. El Jarbeh,Ahmed A. Sharqawi,Heba Z. Smadi,Sami A. Abu-Halaweh,Mohammad M. Abufaraj
In December, China reported a group of pneumonia cases of unknown etiology that were later identified to be caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronaviruses belong to viral family. Initial assessments of the epidemiologic characteristics and transmission dynamics showed that the basic reprodu....
Needle lost in the haystack: multiple reaction monitoring fails to detect Treponema pallidum candidate protein biomarkers in plasma and urine samples from individuals with syphilis
Geert A. Van Raemdonck,Kara K. Osbak,Xaveer Van Ostade,Chris R. Kenyon
hPTPs Isotopically labelled proteotypic surrogate peptides. LOD Limit of detection. MSM Men who have sex with men. PCR Polymerase chain reaction. TPPA Treponema pallidum Particle Agglutination test. RPR Rapid plasma reagin test. COG Clusters of Orthologous Groups. FA ....
Pneumococcal nasopharyngeal carriage and antimicrobial susceptibility profile in children under five in southern Ethiopia
Siraj Hussen,Solomon Asnake,Demelash Wachamo,Birkneh Tilahun Tadesse
EDHS = Central Statistical Agency of Ethiopia, PCV = pneumococcal conjugate vaccine, NP = nasopharyngeal, STGG = skim milk tritons glucose glycerol, and n
Rapid AMI Diagnosis 2020 Lecture
Matthew P. Borloz, MD, FACEP
American College of Emergency Physicians This lecture discusses the protocols and requirements of zero and one-hour rule outs for acute myocardial infarctions (AMI).
VADs, Vests & Zaps 2020 Lecture
Cameron K. Berg, MD, FACEP
American College of Emergency Physicians In this lecture, the focus is on cardiac devices, what they are supposed to do and the ways they may go awry
When Tickers Start to Flicker 2020 Lecture
Kevin C. Reed, MD, FACEP
American College of Emergency Physicians This lecture focuses on some critical pacemaker malfunctions and how to manage them.