Malaria management in children with fever in rural Sierra Leone. Has anything changed after the Ebola outbreak?
Joseph Bangalie Sesay,Olga Denisiuk,Katrina Hann,Rony Zachariah,Francis Lionel Moses,Umaru Dumbuya
A cross-sectional study conducted in 2017. Although the post-Ebola period was included in this evaluation, it was for a relatively short period (six months) which was probably too soon to gauge health system recovery. At the primary healthcare level in the same district and among children under five, we thus performed a new anal....
Needle lost in the haystack: multiple reaction monitoring fails to detect Treponema pallidum candidate protein biomarkers in plasma and urine samples from individuals with syphilis
Geert A. Van Raemdonck,Kara K. Osbak,Xaveer Van Ostade,Chris R. Kenyon
hPTPs Isotopically labelled proteotypic surrogate peptides. LOD Limit of detection. MSM Men who have sex with men. PCR Polymerase chain reaction. TPPA Treponema pallidum Particle Agglutination test. RPR Rapid plasma reagin test. COG Clusters of Orthologous Groups. FA ....
Pneumococcal nasopharyngeal carriage and antimicrobial susceptibility profile in children under five in southern Ethiopia
Siraj Hussen,Solomon Asnake,Demelash Wachamo,Birkneh Tilahun Tadesse
EDHS = Central Statistical Agency of Ethiopia, PCV = pneumococcal conjugate vaccine, NP = nasopharyngeal, STGG = skim milk tritons glucose glycerol, and n
HIV treatment and monitoring patterns in routine practice: a multi-country retrospective chart review of patient care
Baba M Musa,Everistus Ibekwe,Stanley Mwale,Daniel Eurien,Catherine Oldenburg,Gary Chung,Richard F Heller
In addition to choice of appropriate drugs, best practice management of patients with HIV requires monitoring response to treatment and disease progression. This includes tracking clinical immunological, and virological data on patients at diagnosis and on follow-up. There is a rich literature guiding HIV treatment, and guidelin....
Interfacial microscopic examination and chemical analysis of resin-dentin interface of self-adhering flowable resin composite
Tamer M. Hamdy
Adhesive dentistry has seen a paradigm shift from the invasive to be minimally invasive, due to a revolution in bonding systems. There are great demands for simplified restorative materials. A new self-adhering flowable resin composite (Vertise™ Flow Self-Adhering Flowable Composite, Kerr Dental, USA), was recently introduced on....
Andrographolide, isolated from Andrographis paniculata, induces apoptosis in monocytic leukemia and multiple myeloma cells via augmentation of reactive oxygen species production
Hiroki Doi,Taei Matsui,Johannes M. Dijkstra,Atsushi Ogasawara,Yuki Higashimoto,Seiji Imamura,Tamae Ohye,Hiromu Takematsu,Itsuro Katsuda,Hidehiko Akiyama
Many plant-derived products possess a potential for use in chemotherapy. For example, vincristine (VCR) and vinblastine—two natural alkaloids isolated from. Andro has been shown to have anti-tumor activities against solid and hematopoietic tumor cell lines, established from colon-, gastric-, liver-, breast-, and prostatic cancer....
Willingness-to-pay for a hypothetical Ebola vaccine in Indonesia: A cross-sectional study in Aceh
Mudatsir Mudatsir,Samsul Anwar,Jonny Karunia Fajar,Amanda Yufika,Muhammad N. Ferdian,Salwiyadi Salwiyadi,Aga S. Imanda,Roully Azhars,Darul Ilham,Arya U. Timur,Juwita Sahputri,Ricky Yordani,Setia Pramana,Yogambigai Rajamoorthy,Abram L. Wagner,Kurnia F. Jam
Ebola virus disease (EVD), formerly called as Ebola hemorrhagic fever, is a disease characterized by high mortality in human populations. EVD is a highly fatal disease and can be economically burdensome in affected countries. The case fatality rate of EVD ranges from 25% to 100%, with an average of approximately 68%. Development....
Cytotoxic T cells response with decreased CD4/CD8 ratio during mammary tumors inhibition in rats induced by non-contact electric fields
Firman Alamsyah,Rarastoeti Pratiwi,Nisrina Firdausi,Jessica Irene Mesak Pello,Subekti Evi Dwi Nugraheni,Ahmad Ghitha Fadhlurrahman,Luthfi Nurhidayat,Warsito Purwo Taruno
Breast cancer is the most common cancer among women in the world, with one in eight women being at risk of developing it. Skin toxicity or dermatitis arises in electric field therapy due to prolonged direct contact between the electrodes and the skin. Cancer therapy that can re-induce immune response to destroy and clean up tumo....
Efficacy of the combination of crude extracts of Solanum nigrum and Plumbago capensis on Leishmania major
Christine N. Mutoro,Johnson Kinyua,Joseph Ng'ang'a,Daniel Kariuki,Johnson M. Ingonga,Christopher O. Anjili
Leishmaniases are diseases caused by. Studies conducted by. After increasing unresponsiveness to most of the monotherapeutic regimens, combination therapy has found new scope in the treatment of leishmaniasis. The findings of n
Novel multiplex assay for profiling influenza antibodies in breast milk and serum of mother-infant pairs
Kirsi M. Järvinen,Jiong Wang,Antti E. Seppo,Martin Zand
The immune system in neonates and young infants is initially immature, without adequate protection against infections. The dogma is that during infancy, systemic protection is passively provided by transplacental transfer of IgG antibodies and oral and gastrointestinal mucosal protection via breast milk (BM) containing predomina....
Blood Interferon Signatures Putatively Link Lack of Protection Conferred by the RTS,S Recombinant Malaria Vaccine to an Antigen-specific IgE Response
Darawan Rinchai,Scott Presnell,Marta Vidal,Sheetij Dutta,Virander Chauhan,David Cavanagh,Gemma Moncunill,Carlota Dobaño,Damien Chaussabel
About 3.4 billion people, nearly half of the world’s population, live in areas at risk of n
Sirenomelia in a Cameroonian woman: a case report and review of the literature
Frederick LI Morfaw,Philip N Nana
Sirenomelia is an extremely rare congenital malformative disorder, which is often fatal. In the African context, such mermaid-like babies are referred to as ‘mammy-water babies’, and bear an evil connotation associated with witchcraft and sorcery.. The underlying visceral anomalies are usually such that the syndrome is incompati....
Pulmonary embolism presented by syncope in a low-risk patient: a case report
Amr A A Othman,Aly M Tohamy,Ayman K M Hassan
Pulmonary embolism (PE) is a medical emergency that can lead to sudden death. This condition is usually associated with factors that may increase the risk of its occurrence, such as age, high tendency for intravascular coagulation and the presence of certain concomitant conditions such as deep venous thrombosis (DVT) and maligna....
Case Report: Laparoscopic trocar management of a giant paraovarian cyst: a case report
Mohamed Kandil,Tarek Sayyed,Mohamed Zakaria
Paraovarian cysts occur in the broad ligament between the ovary and the tube, predominantly arising from mesothelium covering the peritoneum (mesothelial cyst) but also occasionally arise from the paramesonephric tissue (paramesonephric cysts or Mullerian cysts) and rarely from mesonephric remnants (mesonephric cysts or Wolffian....
In silico screening of known small molecules to bind ACE2 specific RBD on Spike glycoprotein of SARS-CoV-2 for repurposing against COVID-19
Bharath BR,Hrishikesh Damle,Shiban Ganju,Latha Damle
The complete genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is 82% identical to SARS-CoV, both viruses share a common clade encompassing the genus. Drug repurposing is a commercially viable strategy, as it exploits existing drugs, thus significantly reducing the cost and time involved in developing effect....
In vitro evaluation of the anti-diabetic potential of Helichrysum petiolare Hilliard & B.L. Burtt using HepG2 (C3A) and L6 cell lines
Adebowale Emmanuel Aladejana,Graeme Bradley,Anthony Jide Afolayan
Diabetes mellitus (DM) is a complex multi-factorial metabolic anomaly characterized by glucose intolerance and hyperglycaemia, either due to relatively impaired insulin secretion or reduced effectiveness of insulin in facilitating glucose uptake. The worldwide prevalence of diabetes has increased drastically in the last 30 years....
Does the mouse tail vein injection method provide a good model of lung cancer?
Nensi Shrestha,Zabeen Lateef,Orleans Martey,Abigail R. Bland,Mhairi Nimick,Rhonda Rosengren,John C. Ashton
Lung cancer causes more deaths worldwide than any other cancer in both males and females. Mouse models of lung cancer fall into several categories. The first division that can be made is whether the cancer cells are of mouse or human origin. Cancer cells of mouse origin may be grafted onto a host mouse, or induced in tissues by....
A three minutes supine position test reveals higher risk of spinal anesthesia induced hypotension during cesarean delivery. An observational study.
Markos Erango,Arnoldo Frigessi,Leiv Arne Rosseland
SAP; systolic arterial pressure. Hb; hemoglobin concentration. BMI; body mass index. DAP; diastolic arterial pressure. MAP; mean arterial pressure. HR; heart rate. SV; stroke volume. CO; cardiac output. SVR; systemic vascular resistance
The potential impact of age, gender, body mass index, socioeconomic status and dietary habits on the prevalence of dental caries among Egyptian adults: a cross-sectional study
Marwa M.S. Abbass,Nermeen AbuBakr,Israa Ahmed Radwan,Dina Rady,Sara El Moshy,Mohamed Ramadan,Attera Ahmed,Ayoub Al-Jawaldeh
Dental caries is the progressive destruction of the tooth structure by bacterial acids. Data on the incidence of dental caries among Egyptian adults are scarce and are mostly grey literature, which makes this data hard to find. The last published report for the prevalence of caries among Egyptian adults was carried out by the Wo....
Postoperative pain of patients with necrotic teeth with apical periodontitis following single visit endodontic treatment versus multiple visit endodontic treatment using triple antibiotic paste: a randomized clinical trial
Safeya AbdurRahman,Saied M. Abdel Aziz,Shaimaa I. Gawdat,Ahmed M. AbdalSamad
Apical periodontitis (AP) arises primarily by continuous bacterial irritation from the root canals. Recent systematic reviews found that multiple visits with calcium hydroxide did not improve postoperative pain and flare-up and radiographic healing compared to single visit endodontic treatment without interappointment dressing.....
Prevalence of antibiotic-resistant E. coli in retail chicken: comparing conventional, organic, kosher, and raised without antibiotics
Jack M Millman,Kara Waits,Heidi Grande,Ann R Marks,Jane C Marks,Lance B Price,Bruce A Hungate
The use of antibiotics in livestock production may pose health risks to humans, as such usage has been correlated with the occurrence of antibiotic-resistant bacteria isolated from human infections. The organic and RWA labels require specific production methods as stipulated in US federal regulations, whereas the kosher label ad....
High prevalence of diabetes mellitus and impaired glucose tolerance in liver cancer patients: A hospital based study of 4610 patients with benign tumors or specific cancers
Chen Roujun,Yi Yanhua,Li Bixun
High fat and carbohydrate diets, associated with dietary carcinogenesis, contribute to abnormal glucose tolerance and cancer. As an ethnic area, Guangxi Zhuang automonous region (abbreviated as Guangxi) located in southwest China, is well known for its high incidence of liver cancer and nasopharyngeal cancer. This study aimed to....
Fluoxetine pharmacokinetics and tissue distribution suggest a possible role in reducing SARS-CoV-2 titers
Andy R. Eugene
The selective serotonin reuptake inhibitor (SSRI) fluoxetine is a racemic mixture of two stereoisomers,. Considering the COVID-19 clinical symptoms affecting the lungs, fluoxetine lung concentrations would be an important factor to consider when interpreting any study results. Johnson n
Using Lamin B1 mRNA for the early diagnosis of hepatocellular carcinoma: a cross-sectional diagnostic accuracy study
Amani M. Abdelghany,Nasser Sadek Rezk,Mona Mostafa Osman,Amira I. Hamid,Ashraf Mohammad Al-Breedy,Hoda A. Abdelsattar
Hepatocellular carcinoma (HCC) is the most common primary malignancy of hepatocytes, representing the fifth most common cancer, worldwide. The nuclear lamina is a proteinaceous meshwork found below the inner nuclear membrane, composing of intermediate filament proteins: lamin A, lamin C and lamins B1 and B2. Lamins are essential....
Associated predictor covariates of cervical cancer and impact on survival at Khartoum oncology hospital, Sudan
Amanda Elgoraish,Ahmed Alnory
Cancer is a global public health problem, particularly in low- and middle-income countries, due to aging populations as well as broader social and environmental factors such as infectious diseases, education and ethnicity. Cervical cancer is a considerable cause of death among women in developing countries despite the fact that....