Efficacy of the combination of crude extracts of Solanum nigrum and Plumbago capensis on Leishmania major
Christine N. Mutoro,Johnson Kinyua,Joseph Ng'ang'a,Daniel Kariuki,Johnson M. Ingonga,Christopher O. Anjili
Leishmaniases are diseases caused by. Studies conducted by. After increasing unresponsiveness to most of the monotherapeutic regimens, combination therapy has found new scope in the treatment of leishmaniasis. The findings of n
Novel multiplex assay for profiling influenza antibodies in breast milk and serum of mother-infant pairs
Kirsi M. Järvinen,Jiong Wang,Antti E. Seppo,Martin Zand
The immune system in neonates and young infants is initially immature, without adequate protection against infections. The dogma is that during infancy, systemic protection is passively provided by transplacental transfer of IgG antibodies and oral and gastrointestinal mucosal protection via breast milk (BM) containing predomina....
Blood Interferon Signatures Putatively Link Lack of Protection Conferred by the RTS,S Recombinant Malaria Vaccine to an Antigen-specific IgE Response
Darawan Rinchai,Scott Presnell,Marta Vidal,Sheetij Dutta,Virander Chauhan,David Cavanagh,Gemma Moncunill,Carlota Dobaño,Damien Chaussabel
About 3.4 billion people, nearly half of the world’s population, live in areas at risk of n
Sirenomelia in a Cameroonian woman: a case report and review of the literature
Frederick LI Morfaw,Philip N Nana
Sirenomelia is an extremely rare congenital malformative disorder, which is often fatal. In the African context, such mermaid-like babies are referred to as ‘mammy-water babies’, and bear an evil connotation associated with witchcraft and sorcery.. The underlying visceral anomalies are usually such that the syndrome is incompati....
Pulmonary embolism presented by syncope in a low-risk patient: a case report
Amr A A Othman,Aly M Tohamy,Ayman K M Hassan
Pulmonary embolism (PE) is a medical emergency that can lead to sudden death. This condition is usually associated with factors that may increase the risk of its occurrence, such as age, high tendency for intravascular coagulation and the presence of certain concomitant conditions such as deep venous thrombosis (DVT) and maligna....
Case Report: Laparoscopic trocar management of a giant paraovarian cyst: a case report
Mohamed Kandil,Tarek Sayyed,Mohamed Zakaria
Paraovarian cysts occur in the broad ligament between the ovary and the tube, predominantly arising from mesothelium covering the peritoneum (mesothelial cyst) but also occasionally arise from the paramesonephric tissue (paramesonephric cysts or Mullerian cysts) and rarely from mesonephric remnants (mesonephric cysts or Wolffian....
In silico screening of known small molecules to bind ACE2 specific RBD on Spike glycoprotein of SARS-CoV-2 for repurposing against COVID-19
Bharath BR,Hrishikesh Damle,Shiban Ganju,Latha Damle
The complete genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is 82% identical to SARS-CoV, both viruses share a common clade encompassing the genus. Drug repurposing is a commercially viable strategy, as it exploits existing drugs, thus significantly reducing the cost and time involved in developing effect....
In vitro evaluation of the anti-diabetic potential of Helichrysum petiolare Hilliard & B.L. Burtt using HepG2 (C3A) and L6 cell lines
Adebowale Emmanuel Aladejana,Graeme Bradley,Anthony Jide Afolayan
Diabetes mellitus (DM) is a complex multi-factorial metabolic anomaly characterized by glucose intolerance and hyperglycaemia, either due to relatively impaired insulin secretion or reduced effectiveness of insulin in facilitating glucose uptake. The worldwide prevalence of diabetes has increased drastically in the last 30 years....
Does the mouse tail vein injection method provide a good model of lung cancer?
Nensi Shrestha,Zabeen Lateef,Orleans Martey,Abigail R. Bland,Mhairi Nimick,Rhonda Rosengren,John C. Ashton
Lung cancer causes more deaths worldwide than any other cancer in both males and females. Mouse models of lung cancer fall into several categories. The first division that can be made is whether the cancer cells are of mouse or human origin. Cancer cells of mouse origin may be grafted onto a host mouse, or induced in tissues by....
A three minutes supine position test reveals higher risk of spinal anesthesia induced hypotension during cesarean delivery. An observational study.
Markos Erango,Arnoldo Frigessi,Leiv Arne Rosseland
SAP; systolic arterial pressure. Hb; hemoglobin concentration. BMI; body mass index. DAP; diastolic arterial pressure. MAP; mean arterial pressure. HR; heart rate. SV; stroke volume. CO; cardiac output. SVR; systemic vascular resistance
The potential impact of age, gender, body mass index, socioeconomic status and dietary habits on the prevalence of dental caries among Egyptian adults: a cross-sectional study
Marwa M.S. Abbass,Nermeen AbuBakr,Israa Ahmed Radwan,Dina Rady,Sara El Moshy,Mohamed Ramadan,Attera Ahmed,Ayoub Al-Jawaldeh
Dental caries is the progressive destruction of the tooth structure by bacterial acids. Data on the incidence of dental caries among Egyptian adults are scarce and are mostly grey literature, which makes this data hard to find. The last published report for the prevalence of caries among Egyptian adults was carried out by the Wo....
Postoperative pain of patients with necrotic teeth with apical periodontitis following single visit endodontic treatment versus multiple visit endodontic treatment using triple antibiotic paste: a randomized clinical trial
Safeya AbdurRahman,Saied M. Abdel Aziz,Shaimaa I. Gawdat,Ahmed M. AbdalSamad
Apical periodontitis (AP) arises primarily by continuous bacterial irritation from the root canals. Recent systematic reviews found that multiple visits with calcium hydroxide did not improve postoperative pain and flare-up and radiographic healing compared to single visit endodontic treatment without interappointment dressing.....
Prevalence of antibiotic-resistant E. coli in retail chicken: comparing conventional, organic, kosher, and raised without antibiotics
Jack M Millman,Kara Waits,Heidi Grande,Ann R Marks,Jane C Marks,Lance B Price,Bruce A Hungate
The use of antibiotics in livestock production may pose health risks to humans, as such usage has been correlated with the occurrence of antibiotic-resistant bacteria isolated from human infections. The organic and RWA labels require specific production methods as stipulated in US federal regulations, whereas the kosher label ad....
High prevalence of diabetes mellitus and impaired glucose tolerance in liver cancer patients: A hospital based study of 4610 patients with benign tumors or specific cancers
Chen Roujun,Yi Yanhua,Li Bixun
High fat and carbohydrate diets, associated with dietary carcinogenesis, contribute to abnormal glucose tolerance and cancer. As an ethnic area, Guangxi Zhuang automonous region (abbreviated as Guangxi) located in southwest China, is well known for its high incidence of liver cancer and nasopharyngeal cancer. This study aimed to....
Fluoxetine pharmacokinetics and tissue distribution suggest a possible role in reducing SARS-CoV-2 titers
Andy R. Eugene
The selective serotonin reuptake inhibitor (SSRI) fluoxetine is a racemic mixture of two stereoisomers,. Considering the COVID-19 clinical symptoms affecting the lungs, fluoxetine lung concentrations would be an important factor to consider when interpreting any study results. Johnson n
Using Lamin B1 mRNA for the early diagnosis of hepatocellular carcinoma: a cross-sectional diagnostic accuracy study
Amani M. Abdelghany,Nasser Sadek Rezk,Mona Mostafa Osman,Amira I. Hamid,Ashraf Mohammad Al-Breedy,Hoda A. Abdelsattar
Hepatocellular carcinoma (HCC) is the most common primary malignancy of hepatocytes, representing the fifth most common cancer, worldwide. The nuclear lamina is a proteinaceous meshwork found below the inner nuclear membrane, composing of intermediate filament proteins: lamin A, lamin C and lamins B1 and B2. Lamins are essential....
Associated predictor covariates of cervical cancer and impact on survival at Khartoum oncology hospital, Sudan
Amanda Elgoraish,Ahmed Alnory
Cancer is a global public health problem, particularly in low- and middle-income countries, due to aging populations as well as broader social and environmental factors such as infectious diseases, education and ethnicity. Cervical cancer is a considerable cause of death among women in developing countries despite the fact that....
Acute and sub-acute toxicity study of the root extracts of Fagaropsis hildebrandtii in mice and evaluation of their antimicrobial effects
Beatrice Mwende Muia,James Mucunu Mbaria,Laetitia Wakonyu Kanja,Nduhiu Gitahi,Paul Onyango Okumu,Mitchel Otieno Okumu
In the last two decades, the demand for and access to complementary and alternative medicine has grown exponentially. , and. (n
Fasting blood glucose and newborn birth weight of non- diabetic Sudanese women
Abdelmageed Elmugabil,Duria A. Rayis,Ishag Adam,Mohamed F. Lutfi
Abnormal birth weight constitutes a major risk factor for a wide spectrum of childhood morbidities. Previous reports showed accumulating evidence for chronic maternal hypoglycaemian
Molecular study of sapovirus in acute gastroenteritis in children: a cross-sectional study
Maysaa El Sayed Zaki,Raghdaa Shrief,Rasha H. Hassan
Sapovirus is a single strand non enveloped RNA virus that belongs to the. The laboratory methods for detection of sapovirus include enzyme-linked immunosorbent assay, electron microscopy, reverse transcription-polymerase chain reaction (RT-PCR) and next-generation sequencing. Diarrhea represents the second common cause of death....
Case Report: Ostium secundum atrial septal defect with unilateral lung hypervascularity revealing associated right pulmonary artery stenosis
Mehdi Slim,Malick Bodian,Elies Neffati,Essia Boughzela
Atrial septal defect (ASD) is a very common congenital heart disease. The aim of this article is to report, from a case report and literature review, diagnostic challenges and the contribution of simple complementary exams, such as chest X-ray, for the diagnostic orientation of an ASD associated with peripheral pulmonary artery....
Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak?
Tom Sesay,Olga Denisiuk,Rony Zachariah
In 2017, a cross-sectional study. The outbreak was declared over in November 2015. Since then, there have been considerable investments into the health system by Government and development partners. One of the limitations of the 2017 study. We thus conducted a similar country-wide study assessing morbidity and mortality for the....
The frequency distribution of vitamin D Receptor fok I gene polymorphism among Ugandan pulmonary TB patients
Ester L. Acen,William Worodria,Peter Mulamba,Andrew Kambugu,Joseph Erume
According to the World Health Organization (WHO) report on the ‘Use of high burden country lists for TB by WHO in the post-2015 era (WHO/HTM/TB/2015.29), Uganda was removed from the 22 high TB burden countries. However Uganda is still among the 41 high TB/human immunodeficiency virus (HIV) burden countriesn
Determinants of preterm birth in public hospitals in central Ethiopia: an unmatched case-control study
Berhanu Senbeta Deriba,Agumas Fentahun Ayalew,Addis Adera Gebru
ANC; antenatal care, HIV/AIDS; human immunodeficiency virus/acquired immune deficiency syndrome, IFA; iron folic acid, LBW; low birth weight, PIH; pregnancy induced hypertension, PTB; preterm birth, PROM; premature rupture of membrane, WHO; World Health Organization.
Prevalence and risk factors for low back pain among university teaching staff in Nairobi, Kenya: a cross-sectional study
Saikou Yaya Kollet Diallo,Marshal M. Mweu,Simeon Ochanda Mbuya,Mutuku Alexander Mwanthi
Disorders of the musculoskeletal system (MSDs) constitute the second most common cause of disability worldwide – accounting for 169,624,000 disability-adjusted life years (DALYs) as of 2010 which is a 45.5% increase over 10 years. LBP was ranked as the first contributing factor to global disability out of 291 conditions investig....