Acute and sub-acute toxicity study of the root extracts of Fagaropsis hildebrandtii in mice and evaluation of their antimicrobial effects
Beatrice Mwende Muia,James Mucunu Mbaria,Laetitia Wakonyu Kanja,Nduhiu Gitahi,Paul Onyango Okumu,Mitchel Otieno Okumu
In the last two decades, the demand for and access to complementary and alternative medicine has grown exponentially. , and. (n
Fasting blood glucose and newborn birth weight of non- diabetic Sudanese women
Abdelmageed Elmugabil,Duria A. Rayis,Ishag Adam,Mohamed F. Lutfi
Abnormal birth weight constitutes a major risk factor for a wide spectrum of childhood morbidities. Previous reports showed accumulating evidence for chronic maternal hypoglycaemian
Molecular study of sapovirus in acute gastroenteritis in children: a cross-sectional study
Maysaa El Sayed Zaki,Raghdaa Shrief,Rasha H. Hassan
Sapovirus is a single strand non enveloped RNA virus that belongs to the. The laboratory methods for detection of sapovirus include enzyme-linked immunosorbent assay, electron microscopy, reverse transcription-polymerase chain reaction (RT-PCR) and next-generation sequencing. Diarrhea represents the second common cause of death....
Case Report: Ostium secundum atrial septal defect with unilateral lung hypervascularity revealing associated right pulmonary artery stenosis
Mehdi Slim,Malick Bodian,Elies Neffati,Essia Boughzela
Atrial septal defect (ASD) is a very common congenital heart disease. The aim of this article is to report, from a case report and literature review, diagnostic challenges and the contribution of simple complementary exams, such as chest X-ray, for the diagnostic orientation of an ASD associated with peripheral pulmonary artery....
Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak?
Tom Sesay,Olga Denisiuk,Rony Zachariah
In 2017, a cross-sectional study. The outbreak was declared over in November 2015. Since then, there have been considerable investments into the health system by Government and development partners. One of the limitations of the 2017 study. We thus conducted a similar country-wide study assessing morbidity and mortality for the....
The frequency distribution of vitamin D Receptor fok I gene polymorphism among Ugandan pulmonary TB patients
Ester L. Acen,William Worodria,Peter Mulamba,Andrew Kambugu,Joseph Erume
According to the World Health Organization (WHO) report on the ‘Use of high burden country lists for TB by WHO in the post-2015 era (WHO/HTM/TB/2015.29), Uganda was removed from the 22 high TB burden countries. However Uganda is still among the 41 high TB/human immunodeficiency virus (HIV) burden countriesn
Determinants of preterm birth in public hospitals in central Ethiopia: an unmatched case-control study
Berhanu Senbeta Deriba,Agumas Fentahun Ayalew,Addis Adera Gebru
ANC; antenatal care, HIV/AIDS; human immunodeficiency virus/acquired immune deficiency syndrome, IFA; iron folic acid, LBW; low birth weight, PIH; pregnancy induced hypertension, PTB; preterm birth, PROM; premature rupture of membrane, WHO; World Health Organization.
Prevalence and risk factors for low back pain among university teaching staff in Nairobi, Kenya: a cross-sectional study
Saikou Yaya Kollet Diallo,Marshal M. Mweu,Simeon Ochanda Mbuya,Mutuku Alexander Mwanthi
Disorders of the musculoskeletal system (MSDs) constitute the second most common cause of disability worldwide – accounting for 169,624,000 disability-adjusted life years (DALYs) as of 2010 which is a 45.5% increase over 10 years. LBP was ranked as the first contributing factor to global disability out of 291 conditions investig....
Comparison of school based and supplemental vaccination strategies in the delivery of vaccines to 5-19 year olds in Africa - a systematic review
Eposi C. Haddison,Leila H. Abdullahi,Rudzani Muloiwa,Gregory D. Hussey,Benjamin M. Kagina
The Expanded Programme on Immunisation (EPI) was founded in 1974 to provide immunisation services to children, both nationally and globally. Routinely, school aged children and adolescents are not the primary target of EPI and as a result, an immunisation gap among these age groups has been observed in many settings. Several rea....
Genetic analysis of measles virus nucleocapsid gene identifies measles virus isolate of close similarity to Clade A viruses from Nigeria
Adedayo O. Faneye,Johnson A. Adeniji,Babatunde O. Motayo
Measles is an acute viral illness characterised by a prodromal illness of fever, coryza, cough, conjunctivitis and presence of Koplik spots followed by the appearance of a generalised maculopapular rash. The illness is either mild or severe depending on the immune and nutritional status of the infected person. It is caused by me....
Impact of mobile technologies on cervical cancer screening practices in Lagos, Nigeria (mHealth-Cervix): Protocol for a randomised controlled trial
Kehinde S. Okunade,Omolola Salako,Adebola A. Adejimi,Oluwatosin J. Akinsola,Omolara Fatiregun,Muisi A. Adenekan,Olusanjo E. Moses,Bassey Ebenso,Matthew J. Allsop,Rose I. Anorlu,Jonathan S. Berek
Cervical cancer is a major public health problem and is the fourth most common cancer in women worldwide accounting for an estimated 570,000 new cases annually. The use of mobile technologies has increased exponentially in the last few years. Although still limited, there is growing evidence of success in the use of mobile phone....
A Method to adjust for measurement error in multiple exposure variables measured with correlated errors in the absence of an internal validation study
Alexander K. Muoka,George O. Agogo,Oscar O. Ngesa,Henry G. Mwambi
HIV: Human immunodeficiency virus; HBCT: Home-based HIV counseling and testing; HSRC: Human sciences research council; NCD: Non-communicable diseases; BMI: Body mass index; kg: kilogram; n
Cost-effectiveness of once-daily versus twice-daily regimens in the treatment of HIV infection in sub-Saharan Africa: a probabilistic decision model
Muinat B. Sanni-Oba,Olalekan A. Uthman,Jean B. Nachega
Sub-Saharan Africa (SSA) is the region most heavily affected by human immunodeficiency virus (HIV). While the literature has focused on the effectiveness of QD versus twice a day (BID) regimensn
Urine cytological examination: an appropriate method that can be used to detect a wide range of urinary abnormalities
Emmanuel Edwar Siddig,Nouh S. Mohamed,Eman Taha Ali,Mona A. Mohamed,Mohamed S. Muneer,Abdulla Munir,Ali Mahmoud Mohammed Edris,Eiman S. Ahmed,Lubna S. Elnour,Rowa Hassan
Urine cytology is a safe and inexpensive method to diagnose urinary tract abnormalities. It is similarly used for the detection of primary and recurrent urothelial carcinoma. Hematuria is one of the common indications for urine cytology examination. It is also known to be caused by an underlying malignancy in 5% to 10% of patien....
Nutritional and micronutrient status of adolescent schoolgirls in eastern Sudan: A cross-sectional study
Hyder M. Mahgoub,Omar E. Fadlelseed,Ammar H. Khamis,Jalal A. Bilal,Ishag Adam
Adolescents (individuals aged 10 to 19 years) make up approximately one fifth of the world’s population. Research on the nutritional status of adolescent girls is of paramount importance to health planners, as well as to practicing physicians. There is little published data on the nutritional status of adolescent girls in countr....
Molecular characterization of hookworm spp. isolated from food handlers, Khartoum, Sudan: A cross-sectional study
Tarig A. Gamar,Hassan H. Musa,Hisham N. Altayb,Mohamed H. Mohamed,Adam D. Abakar
Ancylostomatidae and strongyl nematodes were known to pose a burden among a variety of mammalian hosts, including humans. The aim of this study was to estimate the prevalence and molecular characterization of hookworms isolated from the stool of food handlers attending Public Health Laboratories in Khartoum state, Sudan, for ann....
Can free open access resources strengthen knowledge-based emerging public health priorities, policies and programs in Africa?
Ernest Tambo,Ghislaine Madjou,Christopher Khayeka-Wandabwa,Emmanuel N. Tekwu,Oluwasogo A. Olalubi,Nicolas Midzi,Louis Bengyella,Ahmed A. Adedeji,Jeanne Y. Ngogang
In recent times, the persistence and unprecedented emergence of rising epidemics and infectious diseases in Africa and worldwide triggered numerous public health declarations of international concern. There is a need for availability of data and information on human-vector-pathogen-ecosystem interfaces, drugs and vaccines develo....
Effect of riboflavin supplementation on blood pressure and possible effect modification by the MTHFR C677T polymorphism: a randomised trial in rural Gambia
Modou Jobe,Mary Ward,Bakary Sonko,Abdul Khalie Muhammad,Ebrima Danso,Helene McNulty,Andrew M Prentice
AE: adverse events; BMI: body mass index; BP: blood pressure; CRF: case report forms; CTSO: clinical trial support office; DAG: data access group; DM: data manager; EGRAC: erythrocyte gluthathione reductase activation coefficient; US FNB: United States Food and Nutrition Board; FAD: flavin-adenine dinucleotide; GCP: Good Clinica....
Funding and COVID-19 research priorities - are the research needs for Africa being met?
Emilia Antonio,Moses Alobo,Marta Tufet Bayona,Kevin Marsh,Alice Norton
: Emerging data from Africa indicates remarkably low numbers of reported COVID-19 deaths despite high levels of disease transmission. However, evolution of these trends as the pandemic progresses remains unknown. More certain are the devastating long-term impacts of the pandemic on health and development evident globally. Resear....
Prevalence of chloroquine and antifolate drug resistance alleles in Plasmodium falciparum clinical isolates from three areas in Ghana
James Abugri,Felix Ansah,Kwaku P. Asante,Comfort N. Opoku,Lucas A. Amenga-Etego,Gordon A. Awandare
Malaria remains a major global health concern especially in sub Saharan Africa.. The use of antimalarial drugs for malaria treatment and prevention has played an integral role in the control of the disease over the decades (. Point mutations in specific genes in the parasite genome are implicated in resistance to specific antima....
Electronic medical records in humanitarian emergencies – the development of an Ebola clinical information and patient management system
Kiran Jobanputra,Jane Greig,Ganesh Shankar,Eric Perakslis,Ronald Kremer,Jay Achar,Ivan Gayton
By November 2015, the West Africa Ebola epidemic had caused 28598 infections and 11299 deaths in the three countries most affectedn
Knowledge and attitude of secondary school students in Nakaseke, Uganda towards HIV transmission and treatment
Patricia Nabisubi,Stephen Kanyerezi,Grace Kebirungi,Gerald Mboowa
The vast majority of people living with human immunodeficiency virus (HIV) are located in low- and middle- income countries, with an estimated 68% living in sub-Saharan Africa. Community-based interventions (CBIs) for the prevention and control of HIV allow increased access and ease availability of medical care to populations at....
The wearing of face masks in African countries under the COVID-19 crisis: luxury or necessity?
Zohra Aloui-Zarrouk,Lahcen El Youssfi,Kingsley Badu,Adeniyi Francis Fagbamigbe,Damaris Matoke-Muhia,Caroline Ngugi,Natisha Dukhi,Grace Mwaura
The views expressed in this article are those of the author(s). Publication in AAS Open Research does not imply endorsement by the AAS.
Case Report: Sudden cardiac death due to ventricular myocardial non-compaction
Syrine Mannoubi,Med Amin Mesrati,Ibn Hadj Amor Hassen,Taha Hasnaoui,Hiba Limem,Marwa Boussaid,Nouha Ben Abdejlil,Abir Aissaoui
Ventricular non-compaction (VNC) is a complex and heterogeneous cardiomyopathy first described in 1926. It is a rare disease with a reported prevalence of 0.014–0.17%. Herein, we report a fatal case of VNC in a 20-year-old male, attested by the autopsy, and we discuss different mechanisms involved in the occurrence of death.
Ethical and scientific considerations on the establishment of a controlled human infection model for schistosomiasis in Uganda: report of a stakeholders’ meeting held in Entebbe, Uganda.
Alison M. Elliott,Meta Roestenberg,Anne Wajja,Christopher Opio,Francis Angumya,Moses Adriko,Moses Egesa,Serah Gitome,Joseph Mfutso-Bengo,Philip Bejon,Melissa Kapulu,Zoe Seager,Tom Lutalo,Winfred Badanga Nazziwa,Asuman Muwumuza,Maria Yazdanbakhsh,Pontiano
Effective vaccines have proven extremely useful in the prevention of infectious diseases, but are still lacking for major poverty-related and neglected infections, including helminth infections. The conventional approach to vaccine development, testing efficacy in human subjects in large Phase III trials after safety and immunog....