Comparison of school based and supplemental vaccination strategies in the delivery of vaccines to 5-19 year olds in Africa - a systematic review
Eposi C. Haddison,Leila H. Abdullahi,Rudzani Muloiwa,Gregory D. Hussey,Benjamin M. Kagina
The Expanded Programme on Immunisation (EPI) was founded in 1974 to provide immunisation services to children, both nationally and globally. Routinely, school aged children and adolescents are not the primary target of EPI and as a result, an immunisation gap among these age groups has been observed in many settings. Several rea....
Genetic analysis of measles virus nucleocapsid gene identifies measles virus isolate of close similarity to Clade A viruses from Nigeria
Adedayo O. Faneye,Johnson A. Adeniji,Babatunde O. Motayo
Measles is an acute viral illness characterised by a prodromal illness of fever, coryza, cough, conjunctivitis and presence of Koplik spots followed by the appearance of a generalised maculopapular rash. The illness is either mild or severe depending on the immune and nutritional status of the infected person. It is caused by me....
Impact of mobile technologies on cervical cancer screening practices in Lagos, Nigeria (mHealth-Cervix): Protocol for a randomised controlled trial
Kehinde S. Okunade,Omolola Salako,Adebola A. Adejimi,Oluwatosin J. Akinsola,Omolara Fatiregun,Muisi A. Adenekan,Olusanjo E. Moses,Bassey Ebenso,Matthew J. Allsop,Rose I. Anorlu,Jonathan S. Berek
Cervical cancer is a major public health problem and is the fourth most common cancer in women worldwide accounting for an estimated 570,000 new cases annually. The use of mobile technologies has increased exponentially in the last few years. Although still limited, there is growing evidence of success in the use of mobile phone....
A Method to adjust for measurement error in multiple exposure variables measured with correlated errors in the absence of an internal validation study
Alexander K. Muoka,George O. Agogo,Oscar O. Ngesa,Henry G. Mwambi
HIV: Human immunodeficiency virus; HBCT: Home-based HIV counseling and testing; HSRC: Human sciences research council; NCD: Non-communicable diseases; BMI: Body mass index; kg: kilogram; n
Cost-effectiveness of once-daily versus twice-daily regimens in the treatment of HIV infection in sub-Saharan Africa: a probabilistic decision model
Muinat B. Sanni-Oba,Olalekan A. Uthman,Jean B. Nachega
Sub-Saharan Africa (SSA) is the region most heavily affected by human immunodeficiency virus (HIV). While the literature has focused on the effectiveness of QD versus twice a day (BID) regimensn
Urine cytological examination: an appropriate method that can be used to detect a wide range of urinary abnormalities
Emmanuel Edwar Siddig,Nouh S. Mohamed,Eman Taha Ali,Mona A. Mohamed,Mohamed S. Muneer,Abdulla Munir,Ali Mahmoud Mohammed Edris,Eiman S. Ahmed,Lubna S. Elnour,Rowa Hassan
Urine cytology is a safe and inexpensive method to diagnose urinary tract abnormalities. It is similarly used for the detection of primary and recurrent urothelial carcinoma. Hematuria is one of the common indications for urine cytology examination. It is also known to be caused by an underlying malignancy in 5% to 10% of patien....
Nutritional and micronutrient status of adolescent schoolgirls in eastern Sudan: A cross-sectional study
Hyder M. Mahgoub,Omar E. Fadlelseed,Ammar H. Khamis,Jalal A. Bilal,Ishag Adam
Adolescents (individuals aged 10 to 19 years) make up approximately one fifth of the world’s population. Research on the nutritional status of adolescent girls is of paramount importance to health planners, as well as to practicing physicians. There is little published data on the nutritional status of adolescent girls in countr....
Molecular characterization of hookworm spp. isolated from food handlers, Khartoum, Sudan: A cross-sectional study
Tarig A. Gamar,Hassan H. Musa,Hisham N. Altayb,Mohamed H. Mohamed,Adam D. Abakar
Ancylostomatidae and strongyl nematodes were known to pose a burden among a variety of mammalian hosts, including humans. The aim of this study was to estimate the prevalence and molecular characterization of hookworms isolated from the stool of food handlers attending Public Health Laboratories in Khartoum state, Sudan, for ann....
Can free open access resources strengthen knowledge-based emerging public health priorities, policies and programs in Africa?
Ernest Tambo,Ghislaine Madjou,Christopher Khayeka-Wandabwa,Emmanuel N. Tekwu,Oluwasogo A. Olalubi,Nicolas Midzi,Louis Bengyella,Ahmed A. Adedeji,Jeanne Y. Ngogang
In recent times, the persistence and unprecedented emergence of rising epidemics and infectious diseases in Africa and worldwide triggered numerous public health declarations of international concern. There is a need for availability of data and information on human-vector-pathogen-ecosystem interfaces, drugs and vaccines develo....
Effect of riboflavin supplementation on blood pressure and possible effect modification by the MTHFR C677T polymorphism: a randomised trial in rural Gambia
Modou Jobe,Mary Ward,Bakary Sonko,Abdul Khalie Muhammad,Ebrima Danso,Helene McNulty,Andrew M Prentice
AE: adverse events; BMI: body mass index; BP: blood pressure; CRF: case report forms; CTSO: clinical trial support office; DAG: data access group; DM: data manager; EGRAC: erythrocyte gluthathione reductase activation coefficient; US FNB: United States Food and Nutrition Board; FAD: flavin-adenine dinucleotide; GCP: Good Clinica....
Funding and COVID-19 research priorities - are the research needs for Africa being met?
Emilia Antonio,Moses Alobo,Marta Tufet Bayona,Kevin Marsh,Alice Norton
: Emerging data from Africa indicates remarkably low numbers of reported COVID-19 deaths despite high levels of disease transmission. However, evolution of these trends as the pandemic progresses remains unknown. More certain are the devastating long-term impacts of the pandemic on health and development evident globally. Resear....
Prevalence of chloroquine and antifolate drug resistance alleles in Plasmodium falciparum clinical isolates from three areas in Ghana
James Abugri,Felix Ansah,Kwaku P. Asante,Comfort N. Opoku,Lucas A. Amenga-Etego,Gordon A. Awandare
Malaria remains a major global health concern especially in sub Saharan Africa.. The use of antimalarial drugs for malaria treatment and prevention has played an integral role in the control of the disease over the decades (. Point mutations in specific genes in the parasite genome are implicated in resistance to specific antima....
Electronic medical records in humanitarian emergencies – the development of an Ebola clinical information and patient management system
Kiran Jobanputra,Jane Greig,Ganesh Shankar,Eric Perakslis,Ronald Kremer,Jay Achar,Ivan Gayton
By November 2015, the West Africa Ebola epidemic had caused 28598 infections and 11299 deaths in the three countries most affectedn
Knowledge and attitude of secondary school students in Nakaseke, Uganda towards HIV transmission and treatment
Patricia Nabisubi,Stephen Kanyerezi,Grace Kebirungi,Gerald Mboowa
The vast majority of people living with human immunodeficiency virus (HIV) are located in low- and middle- income countries, with an estimated 68% living in sub-Saharan Africa. Community-based interventions (CBIs) for the prevention and control of HIV allow increased access and ease availability of medical care to populations at....
The wearing of face masks in African countries under the COVID-19 crisis: luxury or necessity?
Zohra Aloui-Zarrouk,Lahcen El Youssfi,Kingsley Badu,Adeniyi Francis Fagbamigbe,Damaris Matoke-Muhia,Caroline Ngugi,Natisha Dukhi,Grace Mwaura
The views expressed in this article are those of the author(s). Publication in AAS Open Research does not imply endorsement by the AAS.
Case Report: Sudden cardiac death due to ventricular myocardial non-compaction
Syrine Mannoubi,Med Amin Mesrati,Ibn Hadj Amor Hassen,Taha Hasnaoui,Hiba Limem,Marwa Boussaid,Nouha Ben Abdejlil,Abir Aissaoui
Ventricular non-compaction (VNC) is a complex and heterogeneous cardiomyopathy first described in 1926. It is a rare disease with a reported prevalence of 0.014–0.17%. Herein, we report a fatal case of VNC in a 20-year-old male, attested by the autopsy, and we discuss different mechanisms involved in the occurrence of death.
Ethical and scientific considerations on the establishment of a controlled human infection model for schistosomiasis in Uganda: report of a stakeholders’ meeting held in Entebbe, Uganda.
Alison M. Elliott,Meta Roestenberg,Anne Wajja,Christopher Opio,Francis Angumya,Moses Adriko,Moses Egesa,Serah Gitome,Joseph Mfutso-Bengo,Philip Bejon,Melissa Kapulu,Zoe Seager,Tom Lutalo,Winfred Badanga Nazziwa,Asuman Muwumuza,Maria Yazdanbakhsh,Pontiano
Effective vaccines have proven extremely useful in the prevention of infectious diseases, but are still lacking for major poverty-related and neglected infections, including helminth infections. The conventional approach to vaccine development, testing efficacy in human subjects in large Phase III trials after safety and immunog....
Understanding Ethical, Legal and Societal Issues (ELSIs) in Human Biobanking and Genomics for Research and Healthcare in Zimbabwe: The Genomics Inheritance Law Ethics and Society (GILES) initiative
Alice Matimba,Andrew Chimatira,Oppah Kuguyo,James January,Zivayi Mupambireyi,Bazondlile Marimbe-Dube,Vasco Chikwasha,Zibusiso Nyati-Jokomo,Shamiso Muteti,Pedzisayi Mangezvo,Abigail Kangwende,Alfred Chingono,Midion Chidzonga,Jonathan Gandari,James Hakim,Ku
Biobanks of human biospecimen collections are key resources for understanding individual and population diversity, and are integral to healthcare research, medical care, and drug discoveryn
The nexus between improved water supply and water-borne diseases in urban areas in Africa: a scoping review protocol
Nyamai Mutono,James Wright,Henry Mutembei,Josphat Muema,Mair Thomas,Mumbua Mutunga,Samuel Mwangi Thumbi
Urbanization in sub-Saharan Africa (SSA) is growing at 4% annually, with the population living in urban areas projected to double by 2050. Currently, an estimated 40% of the global population is water insufficient. Residents of urban areas in Africa depend on both improved and unimproved water sources including piped water, bore....
Single dose ceftriaxone and metronidazole versus multiple doses for antibiotic prophylaxis at elective caesarean section in Mulago hospital: A randomized clinical trial
Gideon Alex Mugisa,Paul Kiondo,Imelda Namagembe
The single most important risk factor for postpartum maternal infection is caesarean section. Women undergoing caesarean section have a 5-20-fold greater risk of infection and infectious morbidity compared with a vaginal delivery. (. Provision of single dose or combination broad spectrum intravenous antibiotics 30–60 minutes bef....
Predictors of quality of life of older persons in rural Uganda: A cross sectional study
Fred Maniragaba,Betty Kwagala,Emmanuel Bizimungu,Stephen Ojiambo Wandera,James Ntozi
The world is experiencing remarkable and irreversible demographic changes as many people are living longer than ever before. Uganda’s population is largely characterized by young people. Nonetheless, the country’s older population has more than doubled from 686,000 in 1991 to 1,433,596 in 2014 (UBOS 2016. This is attributed to....
“We shall have gone to a higher standard”: Training village heath teams (VHTs) to use a smartphone-guided intervention to link older Ugandans with hypertension and diabetes to care
Joseph Okello Mugisha,Janet Seeley
The number of older adults living with chronic conditions is increasing rapidly in Uganda. Recently, greater attention has been paid to interventions for the prevention and control of chronic conditions in public health care. With the increasing numbers of older adults with chronic conditions, especially hypertension and diabete....
Preliminary evaluation of a Trypanosoma brucei FG-GAP repeat containing protein of mitochondrial localization
Monica Namyanja,Zhi-Shen Xu,Claire Mack Mugasa,Zhao-Rong Lun,Enock Matovu,Zhengjun Chen,George W. Lubega
is a hemoflagellated extracellular protozoan parasite that causes a zoonotic disease known as African Trypanosomiasis. It comprises of three subspecies, namely,. In the GeneDB and TritrypDB genomic databases, n
Characterization of culturable airborne bacteria and antibiotic susceptibility profiles of indoor and immediate-outdoor environments of a research institute in Ghana
Isawumi Abiola,Adiza Abass,Samuel Duodu,Lydia Mosi
Quality of air, especially in indoor environments where people spend 80–95% of their lives is of significant health importance. Bioaerosols, mostly bacterial and fungal spores are actively living complex particles that have been associated with contamination of indoor air. Several species of microorganisms have been isolated acr....
African Pharmacogenomics Consortium: Consolidating pharmacogenomics knowledge, capacity development and translation in Africa
Collet Dandara,Collen Masimirembwa,Yosr Z. Haffani,Bernhards Ogutu,Jenniffer Mabuka,Eleni Aklillu,Oluseye Bolaji
The views expressed in this article are those of the authors. Publication in AAS Open Research does not imply endorsement by the AAS.